The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Loopbaan en solliciteren

Loopbaan en solliciteren

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Promotor: W.T. de Groot

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Op 9 april 2019 verdedigde Yudan Tan haar proefschrift 'The Rome Statute as Evidence of Customary International Law'. Het promotieonderzoek is begeleid door promotor prof. dr. W.A. Schabas.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Studievoorlichting

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

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Sinds de United Nations Group of Governmental Experts on the Developments in the Field of Information and Telecommunications in the Context of International Security (UN GGE) elf aanbevelingen heeft gedaan over verantwoordelijk staatsgedrag omtrent cyberspace is er een discussie gaande over internationale…

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Promotie

Op 3 april promoveert Sebastiaan van der Lubben. Het Leiden University Centre for Linguistics feliciteert Sebastiaan!

Studievoorlichting

What is the role of the rebound effect in achieving environmental savings from transport eco-innovation? Are traditional definitions of the rebound effect adequate in the context of transformative innovations and multidimensional environmental issues?

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: Prof.dr. H.A.G. Wijshoff

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotores: H. Schiessel, G.T. Barkema

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

An interdisciplinary collection of the best international scholarship on Muslim youth.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Promotor: J. Kuiper

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

Promotores: T.H. Oosterkamp, N. de Jonge

Studievoorlichting

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?

Governance and Global Affairs, Instituut Bestuurskunde

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra