Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

De verklaring van natuurkundige Scott Waitukaitis voor de gillende en stuiterende hydrogelballetjes is door verschillende media overgenomen. Zo was Waitukaitis te zien op het RTL 4 journaal van maandag 24 juli.

Op een ogenschijnlijk gewone kubus verschijnt onder druk een patroon van hollingen en bollingen. Er is nu een methode ontwikkeld om zulke 3 dimensionale structuren te ontwerpen en maken met eenvoudige bouwstenen. Publicatie in Nature.

Kleinere computerchips, smallere cameraatjes; ze worden steeds moeilijker om te maken. Maar wat als de bouwstenen zichzelf opbouwen? Natuurkundige Daniela Kraft bedacht een methode om deeltjes aan te sturen in samenklonteren. Publicatie in ACS Nano.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

De tweejarige masteropleiding Physics wordt aangeboden door het Leids Instituut voor Onderzoek in de Natuurkunde. De opleiding is theoretisch en experimenteel. Er is ruime aandacht voor onderzoekstraining. Ook bieden we veel keuzemogelijkheden en op maat gemaakte, individuele studieprogramma’s.

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

Promotie

Promotie

Waterdruppels zweven in een hete pan vanwege het zogenoemde Leidenfrost-effect. Nu hebben natuurkundigen een variatie ontdekt: het Elastische Leidenfrost-effect. Het verklaart waarom hydrogel balletjes op een hete plaat rondspringen en hoge piepgeluidjes maken. Publicatie in Nature Physics op 24 jul…

Hoe complexer het voorwerp, des te ingewikkelder het is om op te vouwen. Een ruimtevaartuig heeft al snel vele motortjes nodig om een instrument-arm in elkaar te vouwen en mensen hebben zelfs moeite met een wegenkaart. Natuurkundigen uit Leiden en Amsterdam hebben nu een structuur ontworpen die zichzelf…

Supervisor: P.J.J. Hooykaas

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…