Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: A. Kros

M van der Stelt

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

De Faculteit der Sociale Wetenschappen is samen met de gemeente Leiden initiatiefnemer van het Leiden Healthy Society Center.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. M. Ubbink

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

The path to rational drug and dose selection

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: B. van de Water

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

CWTS is er trots op een van de oprichters van het 'Initiative for Open Abstracts' te zijn. Dit initiatief roept wetenschappelijke uitgevers op om hun samenvattingen beschikbaar te stellen in een open infrastructuur, oftwel bij Crossref.

Promovenda Luisa Prochazkova deed samen met haar collega's van cognitieve psychologie onderzoek naar de effecten van microdoseringen psychedelische drugs op creativiteit. Hun eerste voorzichtige conclusie: je wordt inderdaad creatiever van een klein beetje LSD.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Donderdag 4 oktober opent het Lorentz Center officieel zijn tweede afdeling op de Leidse bètacampus. Met internationale workshops voor wetenschappers is het Lorentz Center een broedplaats van samenwerking en vernieuwing in de wetenschap. Op alle muren van de nieuwe locatie kan geschreven worden. Ook…

Promotie

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Het initiatief de Nationale Bijentelling van hoogleraar Koos Biesmeijer (Naturalis/Leiden) en Vincent Kalkman (Naturalis) heeft de Communication Initiative Award van NWO ontvangen. De jury looft het initiatief, dat een zeer breed en divers publiek weet te bereiken, en tegelijkertijd bijdraagt aan de…

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Promotor: A.P. IJzerman

Universiteit Leiden is op 28 september met twee projecten aanwezig bij het Discovery Festival, een nachtfestival dat draait om de kick die je krijgt als je nieuwe dingen ontdekt. Antibiotica Gezocht! laat de festivalgangers meewerken in het tijdelijke laboratorium en iSPEX: ‘Meet fijnstof met je smartphone’…

Promotor: M. Ubbink, Co-promotor: G. Siegal

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Bekend is dat drugs via Nederlandse havens gesmokkeld worden, maar bij Bulk Terminal Zeeland speelde iets bijzonders. Pieter Tops legt uit op NPO Radio 1.

Sport Data Center

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Zijn artikel over ‘the war on drugs’ in Colombia en de Filippijnen staat al tijden in de top 5 van meest gedownloade publicaties van Oxford University Press. Nu ontvangt universitair docent Santino Regilme een NIAS-beurs om de wereldwijde 'war on drugs' in kaart te brengen.

Op23 mei 2018 werd het Crown Prince Frederik Center for Public Leadership in Aarhus, Denemarken officieel geopend. Het center is onderdeel van het departement Politieke Wetenschap en staat onder leiding van prof. Lotte Bøgh Andersen. Joris van der Voet en Sandra Groeneveld waren aanwezig bij de feestelijke…

Psychedelische drugs zoals paddo’s en LSD worden door de één omarmd, en door de ander gezien als levensgevaarlijk. Cognitief psycholoog Michiel van Elk dook in de wereld van de psychedelica en schreef er een opvallend nuchter boek over. ‘Zonder ervaring uit eerste hand vond ik mijn verhaal niet comp…