In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Christopher Berg Smiet, die in 2017 aan het LION promoveerde bij Dirk Bouwmeester, heeft de Christiaan Huygensprijs gewonnen voor zijn proefschrift ‘Knots in Plasma’. Op 7 oktober ontving hij een oorkonde, een bronzen beeld van Christiaan Huygens en een prijzengeld van tienduizend euro.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Het is bijna onmogelijk om niet te fronsen als je iemand ziet die boos kijkt. Maar hoe komt dat eigenlijk? Promovendus Chris Riddell doet onderzoek naar hoe we emoties spiegelen en vertelt als KNAW Face of Science over zijn onderzoek.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: Prof.dr. J.W.M. Frenken

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Herken je dat: je ziet je vriend lachen, en plots begin je ook te grijnzen? Promovendus Chris Riddell doet onderzoek naar hoe en waarom we lichaamstaal kopiëren. Hij neemt je als nieuwe Face of Science een jaar lang mee in zijn onderzoek.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

De Nobelprijs voor Scheikunde 2017 is uitgereikt aan Jacques Dubochet, Richard Henderson en Joachim Frank, voor hun ontwikkeling van de cryo-elektronenmicroscopie. Met deze techniek kunnen biomoleculen in 3D in beeld gebracht worden, legt hoogleraar Ultrastructuurbiologie Ariane Briegel uit.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotor: J.W.M. Frenken

'Het Nederlands Centrum voor Elektronen Nanoscopie (NeCEN) is een mooi voorbeeld van een faciliteit die op nationale schaal toegang biedt tot de laatste ontwikkelen op het gebied van cryo-elektronen microscopie', dat schrijft Sriram Subramaniam, een vooraanstaand leider in deze tak van sport, in het…

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Natuurkundige Daniël Geelen ontwikkelde tijdens zijn promotie een nieuwe microscoop die laag-energetische elektronen gebruikt. Zulke elektronen zijn minder schadelijk voor biologische en organische materialen. Geelen promoveert op 31 mei.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Witte wolken ijskoud gas die over de vloer stromen. Magisch, maar ook uitkijken dat je vingers er niet afvriezen. We hebben het natuurlijk over vloeibaar stikstof en helium. Misschien heb je de spectaculaire Freezing Physics-wetenschapsshow van de studentenorganisatie Stichting Rino weleens gezien.…

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: Prof.dr. C.W.J. Beenakker

How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.

Promotie

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Promotie

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Van alle vormen van etnisch en raciaal vooroordeel heeft het antisemitisme verreweg de langste geschiedenis. In zijn nieuwe boek analyseert Chris Quispel het anti-semitisme over vijfentwintig eeuwen.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotie

Promotie

Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.