529 zoekresultaten voor “coen chemistry” in de Publieke website
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Toetsexpert Coen van ’t Veer: ‘Het eindexamen Nederlands is een goed meetinstrument’
Geen voldoende voor je examen Nederlands? Dan geen havo- of vwo-diploma, zegt de inspecteur-generaal van de Inspectie van Onderwijs. Het leidt tot een discussie over een examen dat toch al onder vuur ligt. De finale test voor Nederlands zou bloedeloos zijn, te niche en niet geschikt voor de doelgroep.…
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Coen Maas gaat aan Harvard onderzoek doen naar rechtszaken over belastingontwijking
Begin juni is bekend geworden dat dr. mr. C. (Coen) Maas is toegelaten tot het Visiting Scholar / Visiting Researcher Program van Harvard Law School. Maas zal daar in het academisch jaar 2016/2017 als visiting researcher werken aan zijn onderzoeksproject 'Debating and Judging Corporate Tax Avoidance:…
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Dr. Marcellus Ubbink benoemd tot hoogleraar Protein Chemistry
Dr. Marcellus Ubbink is dit voorjaar bij de Faculteit Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Protein Chemistry. Ubbink kreeg in 2008 een Vici-subsidie van NWO.
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Algorithm selection and configuration for Noisy Intermediate Scale Quantum methods for industrial applications
Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Leiden Institute of Chemistry sleept vier NWO ECHO subsidies binnen
Naast de 2 TOP grants heeft het LIC ook nog 4 ECHO’s binnengehaald voor dr. Francesco Buda, professor Gijs van der Marel met Jeroen Codée, dr. Dmitri Filippov en professor Gilles van Wezel.
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…
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Reactivity of cobalt(II)-dichalcogenide complexes: correlation between redox conversion and ligand-field strength
The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.
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Squaramide-based supramolecular polymers
Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.
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Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
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Arjan de Koning
Wiskunde en Natuurwetenschappen
koning@cml.leidenuniv.nl | +31 71 527 5653
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Sander van Kasteren
Wiskunde en Natuurwetenschappen
s.i.van.kasteren@chem.leidenuniv.nl | +31 71 527 2727
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Synthesis of cyclic peptides as bioconjugation platforms
Cyclic peptides are investigated as a platform to induce different orientations between various ligands.
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Prof. Xander Tielens wordt hoogleraar ‘Physics and Chemistry of the Interstellar Medium‘
Prof. A.G.G.M. (Xander) Tielens wordt bij 1 januari bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar ‘Physics and Chemistry of the Interstellar Medium’. Tielens werkt momenteel als senior onderzoeker bij Ames in Moffett Field, Californië. Ames is een onderdeel van NASA. Daarnaast…
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Telegraaf over snelle infectietest Leids alumniteam
Vier Leidse alumni ontwikkelden een test waarmee huisartsen zelfs op afgelegen plekken in Afrika de aard van luchtweginfecties kunnen vaststellen, voor optimale behandeling. De Telegraaf interviewde Chemistry- en SBB-alumnus Coen Breedveld erover.
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Redox Interconversion between Metal Thiolate and Disulfide Compounds
In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.
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The electrochemical reduction of dioxygen and hydrogen peroxide by molecular copper catalysts
The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…
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Photoinduced processes in dye-sensitized photoanodes under the spotlight: a multiscale in silico investigation
With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…
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Leids alumniteam ‘ruwe diamant’ bij Philips Innovation Awards
Niet alleen in het laboratorium, maar ook bij de huisarts of zelfs op afgelegen plekken in Afrika de aard van een luchtweginfectie vaststellen om die optimaal te behandelen. Dat kan met een test die vier Leidse alumni ontwikkelden. Ze wonnen er de rough diamond-categorie van de Philips Innovations Award…
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Observing what cannot be observed: computational electrochemistry from carbon to hydrogen
In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Stewart McDowall
Wiskunde en Natuurwetenschappen
s.c.mcdowall@cml.leidenuniv.nl | +31 71 527 2727
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AI in Chemistry: minisymposium
Congres/symposium
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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Unconventional fabrication of 2D nanostructures and graphene edges
In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.
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Fate, accumulation and ecotoxicity of copper nanoparticles under environmentally relevant conditions
Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Optimization of quantum algorithms for near-term quantum computers
This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Roxanne Kieltyka
Wiskunde en Natuurwetenschappen
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
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Francesco Buda
Wiskunde en Natuurwetenschappen
f.buda@lic.leidenuniv.nl | +31 71 527 5723
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Mario van der Stelt
Wiskunde en Natuurwetenschappen
m.van.der.stelt@chem.leidenuniv.nl | +31 71 527 4768
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LDE Joint Minor Sustainable Chemistry and Biotechnology
Studievoorlichting
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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A molecular journey : tales of sublimating ices from hot cores to comets
The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.
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NMR Faciliteit
Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…
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From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.