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This study tests whether behavioural problems at a young age are related to early reading and mathematics development.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Cultureel erfgoed wordt over de hele wereld bedreigd door oorlogen, verwaarlozing en plundering. Leer er alles over tijdens een gratis online cursus.

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

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The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

Met meer dan 20.000 Omaanse studenten die Britse programma's volgen in 2017/2018, is het aantal transnationale studenten vrij aanzienlijk in Oman. De transnationale leeromgeving is nieuw voor praktisch al het onderwijzend personeel en voor de studenten. Antonia Lamers onderzocht hoe een TNE-onderwijs-…

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Het onderzoek dat in dit proefschrift wordt beschreven gaat over de ontwikkeling van praktijkkennis van ervaren natuurkunde- scheikunde -en biologiedocenten in de context van de invoering van het vak Algemene Natuurwetenschappen (ANW) in de Tweede Fase van het voortgezet onderwijs.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Lesgeven is een complex beroep. Docenten nemen veel beslissingen, bijvoorbeeld over wat ze onderwijzen, hoe ze dit gaan onderwijzen en hoe ze hun lessen kunnen aanpassen aan de behoeften van leerlingen. Dit vraagt een voortdurende ontwikkeling van nieuwe kennis en vaardigheden om expertise in alle facetten…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Op 12 december promoveert Ria Huijgen-Koolen. Het Leiden University Centre for Linguistics feliciteert Ria!

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Miriam Cohen verdedigde haar proefschrift genaamd “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” op 28 juni 2017. Ze schreef haar proefschrift onder supervisie van prof.dr. L.J. van den Herik en prof. dr. C. Stahn.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: Prof.dr. B. van de Water

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Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Dit proefschrift beschrijft de ontwikkeling van een beoordelingsprocedure voor docenten, toegespitst op beginnende eerstegraads docenten Engels.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Op 30 september 2021 verdedigde Babette van Hazebroek haar proefschrift 'Understanding delinquent development from childhood into early adulthood in early onset offenders'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.W. de Keijser en prof. dr. A. Popma (VUMC).

Promotie