Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Prof.dr. J. Memelink

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: J.W. van Holten

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: Prof.dr. J. Kuiper

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

Una Europa heeft zes transversale thema’s vastgesteld en ingevoerd als leidende beginselen voor samenwerking. Deze thema’s hebben als doel het personeel en de studenten van Una Europa te helpen deze thema's in concrete acties om te zetten.

In samenwerking met Rijksmuseum Boerhaave, naar aanleiding van de tijdelijke tentoonstelling 'Dichter bij het zwarte gat', te zien t/m 5 januari 2025.

Healthcare robots and AI is een onderzoek naar juridische en reguleringsaspecten van robots en kunstmatige intelligentie in de zorg.

Het Leiden Leadership Centre is lid van de Global Leadership Centres Roundtable (GLCR). De Global Leadership Centres Roundtable is het internationale netwerk van universitaire leiderschapscentra.

Promotor: G.J.B. van Ommen

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

In 2015, CML published over 70 papers, contributed to the United Nations conference on climate change in Paris, won awards and advised the Dutch government on the safe use of pesticides. CML awarded 11 PhDs and taught students from all over the world how to contribute to sustainability. We wish you…

In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).

Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Cardiovascular diseases are still a major concern for the global health.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

Ons onderwijsaanbod is breed en divers. Hieronder vindt u alle informatie over de vakken die door de afdeling Bedrijfswetenschappen worden verzorgd. Als u op een vak klikt, wordt u doorgeleid naar de studiegids.

In het najaar van 2021 deelden Cleveringa-hoogleraar Roméo Dallaire en werelddeskundigen hun gedachten over PTSS, kinderrechten, oorlogsmisdaden, humanitair recht en vredeshandhaving in een reeks gesprekken over leiderschap en morele dilemma's in tijden van conflict en crisis.

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Promotie

Leidse wetenschappers en bedrijven ontvangen 1,37 miljoen euro om technologie voor de Einsteintelescoop te ontwikkelen. Deze ondergrondse telescoop gaat zwaartekrachtgolven meten en moet dus extreem gevoelig zijn. Het consortium doet daarom onderzoek naar het dempen van trillingen bij temperaturen rond…

Postdocs, of beginnende onderzoekers, zijn van cruciaal belang voor de Universiteit Leiden. Ze dragen in hoge mate bij aan ons onderzoek. In 2019 waren er ongeveer 400 postdocs werkzaam aan onze faculteiten in Leiden en Den Haag; zij die werkzaam waren bij het LUMC zijn hierbij niet meegeteld.

Aan de hand van drie onderzoekslijnen wordt de verbinding tussen zorg en bestuur gemaakt. Binnen deze drie onderzoekslijnen wordt een multi-level benadering gehanteerd. Dat betekent dat we ons richten op vraagstukken op het niveau van het gezondheidszorgstelsel, het niveau van organisaties en netwerken…

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Supervisor: P.J.J. Hooykaas

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotor: J. Aarts

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.