This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

Promotor: H.W. Lenstra

In this thesis integral points on affine del Pezzo surfaces are studied.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Does knowledge of environmental performance change farmer's behaviour?

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotie

Promotie

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Promotor: S.J. Edixhoven, L.D.J. Taelman

This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

Promotores: S.J. Edixhoven, F. Andreatta

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

This thesis consists of three chapters, the first two of which concern division points of elements of the multiplicative group of a number field.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Promotor: J. Zaanen

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotor: R. Gill, Co-promotor: P. Massart

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Samen met wetenschappers van over de hele wereld streeft de ENIGMA-Anxiety Werkgroep ernaar om meer inzicht te krijgen in de neurobiologische karakteristieken van angststoornissen.

Lees waar je als student van de Universiteit Leiden terecht kunt voor steun als je die nodig hebt en welke afspraken er gelden voor sociale veiligheid in de online leeromgeving.

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotor: P.M. Brakefield

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Promotor: Prof.dr. P. Stevenhagen, Co-promotor: B. de Smit

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Het archeologisch erfgoed van Zuid-Amerika wordt in toenemende mate bedreigd door de uitbreiding van landbouwactiviteiten, de uitbreiding van infrastructuur, illegale houtkap en de huidige bosbranden die het Amazonegebied en andere gebieden van het continent teisteren.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Make use of this time to improve your language skills by signing up for custom-made online language classes.

Promotores: F.H. van Lunteren, F.P. Israel

This Thesis describes a strategy to synthesize 1,2-cis-oligosaccharides modulated by additives, such as dimethylformamide (DMF), triphenylphosphine oxide (Ph3P=O) and N-methyl(phenyl)formamide (MPF), using building blocks that carry solely benzyl type protecting groups and are therefore of uniform r…

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…