1,230 zoekresultaten voor “have screen” in de Publieke website
-
'Oqlanmagan – The Unexonerated': Film Screening and Discussion
Debat, Film Screening and Discussion
-
Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
-
Bestraffingsonderzoek
Binnen het instituut wordt veel onderzoek verricht naar de totstandkoming van straffen en maatregelen in het strafrecht en hoe rechters en andere actoren tot een beslissing komen.
-
CEES/ReCNTR screening: Morality is Good
Kunst en cultuur
-
Postdoctoral Researcher in the project "Do we owe anything to ourselves?"
Sociale Wetenschappen, Psychologie
-
The path to individualised breast cancer screening
Promotie
-
Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
-
Screening the CITY: Optimizing population-based cancer screening in the Netherlands from a primary care perspective
Promotie
-
Film Screening: Crip Camp
Kunst en cultuur, Conference | D&I Symposium
-
Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
-
Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
-
Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
- Storingen ISSC
-
Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
-
Drug Discovery & Safety
In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…
-
Full Professor (Chair) in International Institutional Law (Schermers Chair) (0,2 FTE)
Rechtsgeleerdheid, Instituut voor Publiekrecht, Grotius Centre for International Legal Studies
-
ReCNTR screening: Bo Wang, ‘An Asian ghost story’
Festival
-
Aanmeldprocedure
Nu je weet dat je aan alle toelatingsvoorwaarden voldoet, kun je de aanmeldprocedure starten voor een master aan de Universiteit Leiden.
-
Cursus Actualiteiten Privacy op de Werkvloer
Ontdek de cursus Actualiteiten Privacy op de werkvloer van Leiden Law Academy! Leer over de nieuwste ontwikkelingen die relevant zijn voor Nederland. Lees hier meer!
-
Newborn screening for severe combined immunodeficiency: Breaking the bubble
Promotie
-
Bone and joint disorders: Screening and early clinical drug development
Promotie
-
Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
-
Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
-
Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
-
Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
-
Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
-
X-raying extragalactic gas: warm-hot gas in the EAGLE simulations
I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.
-
Anisotropy, multivalency and flexibility-induced effects in colloidal systems
We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.
-
Exploring charge transport properties and functionality of molecule-nanoparticle ensembles
Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen
-
To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
-
Achtergrondinformatie
Cool Little Kids is een onderzoeksproject ter preventie van angstproblemen bij verlegen en teruggetrokken kinderen van 3-6 jaar die extreem verlegen of angstig zijn.
-
PhD candidate combinatorial drug discovery with macrocycles
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
-
Monsters in the Deep: Using simulations to understand the excess baryonic mass in the centres of high-mass, early-type galaxies
This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…
-
Flows of six heavy metals
Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?
-
Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
-
Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
-
The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
-
The music of language: exploring grammar, prosody and rhythm perception in zebra finches and budgerigars
Promotor: C.J. ten Cate
-
Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
-
Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
-
Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
-
European Lead Factory
Overkleeft
-
Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
-
Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
-
Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
-
Understanding the ecology of the Bornean Pygmy Elephant (Elephas maximus borneensis) in the Sebuku Forest, Nunukan District, North Kalimantan
What is movements and corridors of the Bornean pygmy elephant in Sebuku forest? What is the nature of human-elephant conflict in Nunukan District in time and space? What are the diets of the Bornean elephants related to crop raiding?
-
Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
-
Nieuwe antibiotica
Ziekteverwekkende bacteriën zijn steeds vaker resistent voor de huidige antibiotica. De vraag naar nieuwe antibiotica wordt daarmee steeds groter. Professor Gilles van Wezel zoekt naar nieuwe vormen van antibiotica in goede bacteriën die in de grond leven.
-
Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
-
The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.