This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotores: W. Jiskoot, F. Ossendorp

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Promotie

Promotie

Wat zijn de risico's van nanodeeltjes?

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

Promotie

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

Promotie

Promotie

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotie

Promotie

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Projecten van de afdeling Environmental Biology

In hoeverre hopen nanodeeltjes zich op in planten en dieren, en welke eigenschappen van de deeltjes spelen hierbij een rol? Willie Peijnenburg, hoogleraar Milieutoxicologie en biodiversiteit kreeg een Marie-Curie beurs toegekend om onderzoek te doen naar de milieueffecten van nanodeeltjes.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?

Hoe is het om te werken bij de Universiteit Leiden en hoe zijn wij als werkgever? Diverse medewerkers delen graag hun ervaringen. Bekijk de video’s.

Lezing, Lezing onderdeel van serie

Individuele moleculen zijn extreem moeilijk te zien via hun zwakke fluorescentie. Piepkleine gouden nanostaafjes fungeren als nieuwe antennes om hun signaal 500 maal te versterken. Publicatie op 24 februari in Angewandte Chemie.

Promotor: M.A.G.J. Orrit

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Promotie

Moleculen detecteren met temperatuur in plaats van chemische reacties: dat is wat wetenschappers van het Leids Instituut voor Onderzoek in de Natuurkunde willen doen. Ze ontwikkelen een sensor die speciale nanodeeltjes gebruikt om moleculen in de gaten te houden. Op deze manier kunnen ze bijvoorbeeld…

Promotie

Promotie

Promotie

Promotie

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Promotor: Prof.dr. B. van de Water

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.