Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

LiDAR is een relatief nieuwe meettechniek waarmee het Actueel Hoogtebestand Nederland het hele land zeer nauwkeurig mee heeft ingemeten. Het grote voordeel van deze manier van meten is dat vegetatie geen belemmering vormt. Hierdoor kunnen ook gebieden waar vegetatie de zichtbaarheid van de ondergrond…

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

Promotor: Prof.dr. T. Hankemeier

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotores: K.J. Batenburg, B. Koren

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

Meer dan 50 vrijwilligers onderzochten tussen 11 en 15 oktober samen met studenten archeologie van de Universiteit Leiden verschillende heuvels in het Speulder- en Sprielderbos nabij Putten. Dat deden zij in het kader van Erfgoed Gezocht, een citizen science project van Erfgoed Gelderland en de Universiteit…

Rembrandtroute ter gelegenheid van het 444-jarig bestaan van de Universiteit Leiden en het Rembrandtjaar 2019. Met speciale dank aan Germanisches Nationalmuseum (Neurenberg), The Leiden Collection (New York), Museum De Lakenhal (Leiden), Mauritshuis (Den Haag), Rijksmuseum/Musée du Louvre (Amsterdam/Parijs),…

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Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Binnen Quantum Leiden doen verschillende groepen onderzoek naar quantumnetwerken en quantumsensing.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Promotor: Prof.dr. D. Bouwmeester

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotor: Prof.dr. H.J.A. Rottgering

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Twee hoogleraren die op dezelfde dag hun oratie uitspreken, dat is een zeldzaamheid aan de Universiteit Leiden. Berna Güroğlu en Ellen de Bruijn zijn gespecialiseerd in aanverwante vakgebieden: beiden onderzoeken de invloed van sociale context op hersenprocessen. Güroğlu doet dat bij adolescenten, De…

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Lees hier de publicaties die over het Erfgoed Gezocht project zijn verschenen.

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

Promotor: H.W. Lenstra

Data Science (DS) and Artificial Intelligence (AI) are omni-present and have the potential to be incorporated in various fields. However, in order to live up to this expectation, a good understanding of the techniques, their implications and limitations is required. In this minor you develop insights…

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