Het onderzoek dat in dit proefschrift wordt beschreven gaat over de ontwikkeling van praktijkkennis van ervaren natuurkunde- scheikunde -en biologiedocenten in de context van de invoering van het vak Algemene Natuurwetenschappen (ANW) in de Tweede Fase van het voortgezet onderwijs.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Lesgeven is een complex beroep. Docenten nemen veel beslissingen, bijvoorbeeld over wat ze onderwijzen, hoe ze dit gaan onderwijzen en hoe ze hun lessen kunnen aanpassen aan de behoeften van leerlingen. Dit vraagt een voortdurende ontwikkeling van nieuwe kennis en vaardigheden om expertise in alle facetten…

Docenten in het hoger onderwijs zijn experts in wát zij doceren, maar niet noodzakelijk in hóe zij dit zouden moeten doen. Dit komt omdat zij vaak weinig tot geen training hebben gehad in het lesgeven. Daarnaast zijn zij over het algemeen meer georiënteerd op hun eigen vakgebied dan op hun rol als docent.…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Op 12 december promoveert Ria Huijgen-Koolen. Het Leiden University Centre for Linguistics feliciteert Ria!

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Miriam Cohen verdedigde haar proefschrift genaamd “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” op 28 juni 2017. Ze schreef haar proefschrift onder supervisie van prof.dr. L.J. van den Herik en prof. dr. C. Stahn.

This thesis aims to address offshore wind energy (OWE)-related environmental impacts.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Promotor: Prof.dr. B. van de Water

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

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Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Dit proefschrift beschrijft de ontwikkeling van een beoordelingsprocedure voor docenten, toegespitst op beginnende eerstegraads docenten Engels.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Op 30 september 2021 verdedigde Babette van Hazebroek haar proefschrift 'Understanding delinquent development from childhood into early adulthood in early onset offenders'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.W. de Keijser en prof. dr. A. Popma (VUMC).

Promotie

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Dit proefschrift omvat vier deelstudies waarin de ‘pedagogische vakkennis’ (pedagogical content knowledge ofwel PCK) van bètadocenten wordt onderzocht.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Promotor: Prof.dr. J.N. Kok

Het terugdringen van agressie is in de afgelopen jaren in toenemende mate een maatschappelijke prioriteit geworden. Agressie in de vroege kindertijd vergroot de kans op latere agressieproblemen en antisociaal gedrag.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

De Edinburgh Medal 2016 is uitgereikt aan zowel Kevin Govender van de Office of Astronomy for Development (OAD) als de International Astronomical Union (IAU). De prijs is een erkenning voor het wereldwijd bevorderen van onderwijs en technologie door middel van sterrenkunde. Het programma is het geesteskind…

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Op 26 juni 2019 verdedigde Lisa Louwerse haar proefschrift 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. Het promotieonderzoek is begeleid door promotor prof. mr. C.A.P. Hillion.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Het boek 'The United Nations Convention on the Rights of the Child' is het resultaat van de conferentie – ’25 Years CRC’ – die in november 2014 in Leiden werd gehouden.