2,339 zoekresultaten voor “the design” in de Publieke website
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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On the geometry of fracture and frustration
Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli
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vaccines for immune modulation: from antigen selection to nanoparticle design
Promotie
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Design and synthesis of next generation carbohydrate-mimetic cyclitols: towards deactivators of inverting glycosidases and glycosyl transferases
Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.
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Research Design in Politcal Science: Het nieuwe boek van Dimiter Toshkov is nu beschikbaar
Het nieuwe boek van Dimiter Toshkov - universitair hoofddocent Bestuurskunde aan de Faculteit Governance and Global Affairs - is onlangs gepubliceerd door Palgrave Macmillan.
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: Prof.dr. J.N. Kok
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Management of small-scale -African fisheries: The Case of Elephant Marsh in Malawi
How does the management of Elephant Marsh Fishery in Malawi relate to wider contexts of policies, theories and regions? And how can the current management system be adapted to achieve long-term sustainability of the fishery?
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Collaborative learning in higher education: design, implementation and evaluation of group learning activities
Samenwerkend leren in het hoger onderwijs: ontwerp, implementatie en evaluatie van groepsleeropdrachten
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Design and evaluation of video portfolios: reliability, generalizability, and validity of an authentic performance assessment for teachers
In welke mate zijn beoordelingen op basis van een videodossier betrouwbaar, generaliseerbaar en valide?
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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Deciphering the complex paramagnetic NMR spectra of small laccase
Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.
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Andrea Herrera Jaramillo
Wiskunde en Natuurwetenschappen
j.a.herrera.jaramillo@cml.leidenuniv.nl | +31 71 527 2727
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Eindpresentatie Design of Justice
Op 19 mei 2021 heeft de eindpresentatie plaatsgevonden van de cursus Design of Justice: the juvenile court of the future.
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Adding fuel to the conflict : how gas reserves complicate the Cyprus question
In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.
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Centre for the Arts in Society (LUCAS)
Het Leiden University Centre for the Arts in Society (LUCAS) onderzoekt beeldende kunsten, design, film, fotografie, digitale media en literatuur in de westerse wereld.
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The environmental rebound effect: a new paradigm for an old challenge. The case of transport eco-innovation
What is the role of the rebound effect in achieving environmental savings from transport eco-innovation? Are traditional definitions of the rebound effect adequate in the context of transformative innovations and multidimensional environmental issues?
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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PROGENY
How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.
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Impacts of the use of Natural Resources and Products
Development of an aggregated impact indicator to measure decoupling.
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Algorithms help improve building design
Modern optimization algorithms offer solutions for architectural decisions like spatial, structural and energy efficiency. A young computer scientist from Leiden University co-authored a paper that won the Best Paper Award at a leading conference in Krakow during the summer.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Engagement of citizens and public professionals in the co-production of public services
The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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Improved hard real-time scheduling and transformations for embedded Streaming Applications
This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.
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Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Joran Lammers
Wiskunde en Natuurwetenschappen
j.a.lammers@cml.leidenuniv.nl | +31 71 527 2727
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Tracing the journey of the sun and the solar siblings through the Milky Way
Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Squaramide-based supramolecular polymers
Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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On the Emergence of the Energy Transition
The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.
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Uncontrollable: Data subject rights and the data- driven economy
Op 7 februari 2019 verdedigde Helena Ursic-Vrabec haar proefschrift 'Uncontrollable: Data subject rights and the data- driven economy'. Het promotieonderzoek is begeleid door promotor prof. dr. S. van der Hof.
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The colours of the extreme universe
This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.
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The application of the United Nations Convention on the Rights of the Child by national courts
Op 3 december 2019 verdedigde Meda Couzens haar proefschrift 'The application of the United Nations Convention on the Rights of the Child by national courts'. Het promotieonderzoek is begeleid door promotoren prof.dr. T. Liefaard en prof.mr. J.J. Sloth-Nielsen.
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The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age
Op 27 juni 2019 verdedigde Barry Bussey zijn proefschrift 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. Het promotieonderzoek is begeleid door promotor prof. dr. P.B. Cliteur.
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Towards an effective biodiversity conservation and governance in the Pontocaspian region
Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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It's just a phase: High-contrast imaging with patterned liquid-crystal phase plates to facilitate characterization of exoplanets
This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.