561 zoekresultaten voor “to get superconductivity” in de Publieke website
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To foreignise or to domesticate? How media vary cross-nationally in their degrees of incorporating foreign events
In dit artikel onderzoeken de auteurs de mate van domesticatie van buitenlandse gebeurtenissen als onderzoeksonderwerp.
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Reasoning about object-oriented programs: from classes to interfaces
Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Methods to simulate fermions on quantum computers with hardware limitations
This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates
We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Statistical learning for complex data to enable precision medicine strategies
Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.
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Lithium-ion batteries and the transition to electric vehicles
The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.
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Student-teachers' commitment to teaching
De motivatie van studenten van lerarenopleidingen voor het beroep van leraar is afhankelijk van diverse factoren. Lerarenopleidingen kunnen de betrokkenheid van hun studenten beïnvloeden.
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Positioning of current Environmental tools & an outlook to the future
Review of new technical decisionsupport systems in the environmental field, and application in water management decission processes.
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Adaptive responses to environmental changes in Lake Victoria cichlids
Promotor: M.K. Richardson, Co-Promotor: F. Witte
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From the Rule of Law to a Culture of Justice: a Practitioner’s Challenge to Policy Thinkers
Irene Khan, expert op het gebied van mensenrechten, werpt een aantal vragen op: Wat kan men verstaan onder een ‘Culture of Justice’? Wie bepaalt wat 'Justice' is? Hoe realistisch is de bevordering van ‘Rule of Law’ en ‘Justice’ in landen waar sprake is van ernstige conflictsituaties en armoede?
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Classical and paramagnetic NMR spectroscopy applied to different protein systems
Promotor: Prof.dr. M. Ubbink
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Quantitative pharmacology approaches to inform treatment strategies against tuberculosis
Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.
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A new method to reconstruct the structure from crystal images
Promotor: J.P. Abrahams, Co-promotor: T. Grüne
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Contributions to the phylogeny of the haplolepideous mosses
The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…
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Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.
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Periodic pulse solutions to slowly nonlinear reaction-diffusion systems
Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Online Course Introduction to Comparative Indo-European Lingistics
Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…
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Politics, Culture and National Identities, 1789 to the Present (MA)
De masteropleiding Politics, Culture and National Identities, 1789 to the Present van de Universiteit Leiden geeft je de mogelijkheid om op een nieuwe manier Europese politiek en identiteit te onderzoeken.
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From grains to planetesimals: the microphysics of dust coagulation
Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)
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The Demographics of Protoplanetary Disks: from Lupus to Orion
The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
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Tuning in to star-planet interactions at radio wavelengths
Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.
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Swimming Bass under Pounding Bass: fish response to sound exposure
Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Deciphering fermionic matter: from holography to field theory
Promotor: K.E. Schalm, Co-promotor: S.S. Lee
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions
Op donderdag 16 november 2017 is Thomas Leclerc gepromoveerd op zijn proefschrift ‘A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions. Contribution to the Study of Interactions between Legal Orders of International Law’. Zijn promotoren zijn prof.dr. P.M.J. Mendes De Leon en prof. L.…
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Geometric approach to evolution problems in metric spaces
Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans
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The Right to Travel by Air of Persons with Disabilities
Op donderdag 16 november 2017 heeft Lalin Kovudhikulrungsri haar proefschrift ‘The Right to Travel by Air of Persons with Disabilities’ verdedigd. Haar promotoren zijn Prof.dr. P.M.J. Mendes De Leon en Prof.mr.dr. A.C. Hendriks.
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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From midplane to planets : the chemical fingerprint of a disk
This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.
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The physics of nanowire superconducting single-photon detectors
Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)
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Professional learning: what teachers want to learn
Het doel van dit promotieonderzoek was te onderzoeken wat leraren zelf willen leren. De centrale onderzoeksvraag luidde: wat, hoe en waarom willen leraren leren? En hangt dit af van hun jaren leservaring en de school waarin ze werken?
- From basic research to therapy development for neuromuscular disorders
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Pair configurations to molecular activity coefficients: PAC-MAC
This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Catalysis of the electrochemical water oxidation to oxygen
Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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Applications of topology to Weyl semimetals and quantum computing
This thesis covers various applications of topology in condensed matter physics and quantum information.