Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotores: Wim Jiskoot; Ferry Ossendorp

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: Prof.dr. T.H.W. Bäck

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: Peter Stevenhagen

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Heart failure is a major health care problem with high mortality.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Promotor: F. Arbab

This thesis applies data mining in commercial settings in the telecommunications industry.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotor: E.F. Smets, Co-promotor: J. Geml

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: Prof.dr. B. van de Water

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Including modelling as part of software development appears to have various benefits.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotor: A. Kros

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

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