971 zoekresultaten voor “have en vaatziekten” in de Publieke website
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The Monetary Valuation of Water-related Ecosystem Services
While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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The spin evolution of accreting and radio pulsars in binary systems
Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.
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Isotopes and the characterization of extrasolar planets
Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.
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Prosecutorial Discretion in International Criminal Justice
Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.
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Student for a day International Studies
Studievoorlichting
- Summer School: "Manuscript Studies: Codicology and Digital Techniques" (5 ECTS)
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Postdoctoral researcher in African Studies
Afrika-Studiecentrum Leiden
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4 Veni-subsidies voor de faculteit, 11 voor Leidse onderzoekers
De onderzoeksvoorstellen van wiskundige Peter Bruin, natuurkundige Daniela Kraft, bio-farmaceut Rawi Ramautar en sterrenkundige Catherine Walsh en nog 7 onderzoeksvoorstellen van talentvolle Leidse wetenschappers zijn gehonoreerd met een Veni-subsidie van 250.000 euro. Landelijk zijn 155 Veni’s vers…
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
- Postdoc in Structures and Homotopy in Optimisation
- Contact
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Regelmatige bedtijden zijn gezond, blijkt uit winnend artikel PRE-Classes 2020
In tijden van thuiswerken is het maar al te verleidelijk om lekker uit te slapen. Maar is dat wel verstandig? Niet als je de volgende dag weer vroeg op moet, weet PRE-student Alyssa Goudswaard. Met haar artikel over de effecten van een verwarde biologische klok op het lichaam won zij de prijs voor beste…
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Verslag ledenvergadering - 19 februari 2015
Op 19 februari 2015 vond de 993e vergadering van het Natuurwetenschappelijk Gezelschap Leiden (NGL) plaats. Na het succes van de vorige lezing werd het Cell Observatory goed gevuld door niet alleen leden maar ook veel bezoekers, waaronder veel jonge alumni van de Faculteit der Wiskunde en Natuurwete…
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NWO-subsidie voor Pavlov-reactie tijdens de slaap
Andrea Evers en Jelle van Leusden hebben een NWO-subsidie ontvangen in het programma Onderzoekstalent. Hiermee gaan zij onderzoeken of het mogelijk is om automatisch gereguleerde processen, zoals het circadiaanse ritme, à la Pavlov te conditioneren tijdens de slaap.
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Wie zorgt er voor de mantelzorger?
Een op de tien mantelzorgers is overbelast. Om deze mantelzorgers die risico lopen om overbelast te raken optimaal te ondersteunen, is het belangrijk om ze te identificeren. Winnie Gebhardt en Yvette Meuleman brengen in opdracht van ZonMW risicoprofielen in kaart.
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Kiem-initiatief mondt uit in plan voor grotere subsidieaanvraag
Het interdisciplinaire Kiem-project ‘Violence as a Population Health problem’ heeft geleid tot een plan voor de aanvraag van een grote, nog nader te bepalen, onderzoekssubsidie. De snelkookpansessie, die de kern vormde van het project, bleek zeer effectief.
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Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates
We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…
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Effects of light at night on plants and their interactions with other species
What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?
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Parttime programma
Sinds 2021 is de master ook in deeltijd te volgen, een parttime opleiding van 2-3 dagen per week, waarvan één vaste, verplichte dag op vrijdag.
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Insolvency Office Holder-project
It researches (the possibilities for) the development of a set of principles and best practices for insolvency office holders by comparing multilateral treaties and soft law recommendations and national legislation within Europe.
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SMALL Savannah : an information system for the integrated analysis of land use change in the Far North of Cameroon
Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan
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Empathic or anxious mistakes?
A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments
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Searching by Learning: Exploring Artificial General Intelligence on Small Board Games by Deep Reinforcement Learning
In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…
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Iber Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Through the magnifying glass
Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.
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Electroreduction of nitrate and carbon dioxide on copper electrodes: a mechanistic study
In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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High-resolution integral-field spectroscopy of exoplanets
This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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On the Power Efficiency, Low latency, and Quality of Service in Network-on-Chip
In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.
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Phylogenetic ecology of octocoral - gastropod associations
Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Inferno Worlds
A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Evaluation of the environmental impact of products (EIPRO)
Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Business incubators: the impact of their support
A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.
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Bayesian learning: challenges, limitations and pragmatics
This dissertation is about Bayesian learning from data. How can humans and computers learn from data?
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Exploring strange new worlds with high-dispersion spectroscopy
Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…
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Evaluation of Different Design Space Description Methods for Analysing Combustion Engine Operation Limits
Promotor: Prof.dr. T.H.W. Bäck
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Convergent molecular evolution of toxins in the venom of advanced snakes (Colubroidea)
The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Signalling pathways that control development and antibiotic production in streptomyces
Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Complex multiplication of abelian surfaces
Promotor: Peter Stevenhagen