Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Artful Mathematics: The Heritage of M. C. Escher

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Promotor: Prof.dr.ir. E. Deprettere

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Promotores: J.N. Kok, H.J. Hoogeboom

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Promotor: T.J. Aartsma, Co-promotor: R.N. Frese

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

Promotor: Prof.dr. G.J. Kroes

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Possible improvements for the assessment of abiotic depletion in LCA.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

De effectiviteit van een vroeg interventieprogramma voor angstige peuters in Nederland

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Dit proefschrift heeft tot doel een kritische kijk te geven op het bewustzijn van de Vietnamese belanghebbenden in het voortgezet onderwijs met betrekking tot de fundamentele educatieve democratische waarden en democratische handelingen binnen de ‘fysieke’ en digitale leeromgeving.

Het Centre for Public Values & Ethics (CPVE) is een interdisciplinair academisch expertisecentrum met als doel het verrichten en verspreiden van wetenschappelijk onderzoek naar waardengeladen vraagstukken in de publieke sector. In het bijzonder wordt gekeken naar de ethiek van de publieke ambtsvervulling…

We are very excited to announce our Sustainability Series for 2023-2024. Each month an interactive workshop will be organised that discusses a specific theme of sustainability. Interested about sustainability? Do not hesitate to sign up to our events !