Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

How can prospective LCA be streamlined in a way that its practical application in research and technology development increases?

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Bike Labyrinth is internationaal marktleider in het aanbieden van virtual reality-oefeningen voor ouderenzorg.

Op 11 november organiseerde de bacheloropleiding Molecular Science and Technology een corona-proof diploma-uitreiking met een bijzondere afstudeerder: de 18-jarige Ruard van Workum. Al van jongs af aan ontwikkelde Ruard een passie voor scheikunde. Hij begon op 15-jarige leeftijd met de opleiding Molecular…

Sensatieverhalen vertellen, voordelen overdrijven en risico's onderschatten: ergens een 'hype' over creëren klinkt niet als iets waar een verantwoordelijke wetenschapper zich aan zou wagen. Of kunnen we een hype ook op een 'goede manier' inzetten? Wat kunnen we bereiken door discussies over de quantumtoekomst…

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotie

Vijf van de negen nieuwe Medical Delta-hoogleraren die een dubbelaanstelling hebben gekregen, zijn verbonden met de Universiteit Leiden/LUMC. Het zijn de psychologe Andrea Evers en vier LUMC-hoogleraren.

Commerciële bedrijven die gebruik willen maken van de expertise en faciliteiten worden doorverwezen naar LAB , de commerciële eenheid die verantwoordelijk is voor gespecialiseerd laboratoriumwerk.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Cristina del Real, universitair docent Cyber Crisis bij het Institute Security and Global Affairs, nam deel aan de presentatie van het Office of Science and Technology (OficinaC) voor het Spaanse Congres van Afgevaardigden (het Spaanse parlement). Ze is een expert in cyber security, een van de vier…

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

In 2020 zijn de stimuleringsprogramma's van de Universiteit Leiden gestart, met als één van de programma's regeneratieve geneeskunde.

Promotor: B. van de Water

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Hoe bied je met simpele middelen tóch hoogwaardig en interessant onderwijs? Hierover sprak Universe Awareness van de Universiteit Leiden tijdens het wetenschapsfestival in Botswana. Met onder andere een laserexperiment van huishoudelijke materialen toonden zij de mogelijkheden om jongeren te interesseren…

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Promotor: B. van de Water

Een overzicht van awards en prijzen die in 2020 zijn toegekend aan onze medewerkers en studenten, maar ook bijzondere benoemingen aan de Universiteit Leiden en andere instellingen.

Promotie

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros