Promotie

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotie

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

This thesis describes the evaluation of novel natural products with antibacterial activity enabled by total chemical synthesis.

Studievoorlichting

Studievoorlichting

This thesis introduces the concept of

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Afstudeerceremonie

Afstudeerceremonie

Festival

Promotie

Promotie

Neem contact op met de afdeling Environmental Biology

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Promotie

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Projecten van de afdeling Environmental Biology

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Een uitgebreid overzicht van het onderwijs van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website

Een uitgebreid overzicht van de publicaties van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website

Een uitgebreid overzicht van het onderzoek van de afdeling Environmental Biology is beschikbaar op de Engelse versie van de CML-website