1,523 zoekresultaten voor “system cell biology” in de Publieke website
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Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification
Op 29 januari 2019 verdedigde Robbert van Eijk proefschrift 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. Het promotieonderzoek is begeleid door promotor prof. dr. H.J. van den Herik.
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Statistical physics and information theory for systems with local constraints
Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Comparative biology of common and grey seals along the Dutch coast
What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?
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Anisotropy, multivalency and flexibility-induced effects in colloidal systems
We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Exploring and exploiting activity-based protein profiling in chemical biology and medicinal chemistry
Overkleeft
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Waste Collection Systems Assessed and Good Practices Identified (COLLECTORS)
What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?
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Liposomes as delivery system for allergen-specific immunotherapy
In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.
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Tax and Society: Building a Sustainable and Fair Tax System
Tax scandals, like the Panama Papers, the Paradise Papers, and the Pandora Papers, have made taxation a major topic of public debate. Learn more about this in the new minor Tax and Society: Building a Sustainable and Fair Tax System.
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Steady-State Analysis of Large Scale Systems
Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma
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Geometry and Topology in Active and Driven Systems
The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).
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Classical and paramagnetic NMR spectroscopy applied to different protein systems
Promotor: Prof.dr. M. Ubbink
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design
Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.
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Civil Liability for Damage caused by Global Navigation Satellite System
Op 17 december 2018 verdedigde Dejian Kong zijn proefschrift 'Civil Liability for Damage caused by Global Navigation Satellite System'. Het promotieonderzoek is begeleid door promotor prof. dr. P.M.J. Mendes de Leon.
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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Dual-Appointment PhD Candidate and Junior System Administrator, Software Optimization and Compiler
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.
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scheduling of cyclo-static dataflow and its application in system-level design
Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov
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Embedded System Software Engineer (Research and Education support) (0.8-1.0fte)
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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A novel supramolecular system for membrane fusion and biosensing
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Silicon pore optics for high-energy optical systems
This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.
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Duality, bosonic particle systems and some exactly solvable models of non-equilibrium
Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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The role and analysis of molecular systems in electrocatalysis
Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.
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Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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PhD: sustainability & circularity-based decision support systems (industrial digital twins)
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
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SMALL Savannah : an information system for the integrated analysis of land use change in the Far North of Cameroon
Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan
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Protostellar jets and planet-forming disks: Witnessing the formation of Solar System analogues with interferometry
The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems
Op 14 november 2019 verdedigde Luis Fiallos Pazmino zijn proefschrift 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. E.C.P.D.C. De Brabandere.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).