328 zoekresultaten voor “target therapy” in de Publieke website
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Measuring gold molecular gas across cosmic time
Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…
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disease: multimodality imaging for risk stratification and evaluation of therapy
Promotie
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Improving response and reducing toxicity to immune checkpoint blockade therapy in melanoma
Promotie
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The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
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Random walks on Arakelov class groups
The main topic of this PhD thesis is the Arakelov ray class group of a number field, an algebraic object that contains both the ideal class group structure and the unit group structure.
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Inverse design of curvature-sensing antiviral peptides
Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.
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Judith BovéeFaculteit Geneeskunde
j.v.m.g.bovee@lumc.nl | +31 71 526 9111
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Marike KooistraFaculteit der Sociale Wetenschappen
m.j.kooistra@fsw.leidenuniv.nl | +31 71 527 1726
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Light therapy for cancer-related fatigue in (non-)Hodgkin Lymphoma Survivors
Promotie
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Text-mining real-world data to evaluate systemic anti-cancer therapy
Promotie
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Targeting tumors using T-cell receptor gene transfer
Promotie
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Publicaties
Lees meer over selectief mutisme
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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SiTaSol
What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?
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characterization of uveal melanoma patients treated with proton beam therapy
Promotie
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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NeCEN
Met de krachtige elektronenmicroscopen van NeCEN bestuderen we afwijkingen aan cellen van bloedvaten bij hart- en vaatziekten, de wisselwerking tussen ziekteverwekkers en gastheren bij infectieziekten, moleculaire processen die kanker veroorzaken, de interactie tussen geneesmiddelen en target-eiwitten.…
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Nieuwe hoogleraar gaat medicijnen ontwikkelen binnen academische wereld
Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.
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Improving Side-effects and Quality of Life of Systemic Therapy in Oncology
Promotie
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Lioe-Fee de Geus-OeiFaculteit Geneeskunde
l.f.de_geus-oei@lumc.nl | +31 71 526 9111
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CRB1 gene therapy coming of age: Mechanistic insight and rAAV assays on mouse & human retinal organoid models
Promotie
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Bridging the gap, Pelvic floor physical therapy in the treatment of chronic anal fissure
Promotie
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Laura Heitman genomineerd voor Prix Galien
Laura Heitman van het Leiden Academic Centre for Drug Research (LACDR) is genomineerd voor de Prix Galien Research Award. Deze belangrijke farmaceutische prijs bekroont jonge, vooraanstaande onderzoekers wiens wetenschappelijk onderzoek van grote betekenis is voor fundamenteel of klinisch geneesmidd…
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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In vitro models of bone-forming tumours: from target to treatment
Promotie
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
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Understanding and Targeting Coronaviruses Exploring advanced cell culture models and host-directed antiviral strategies
Promotie
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joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
Promotie
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Shining Light on PAHs in Space
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Off the wall: characterisation and exploitation of a cell wall deficient life style in filamentous actinomycetes
Almost all bacteria are enveloped by a cell wall that provides cellular protection.
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.