667 zoekresultaten voor “active some matter” in de Publieke website
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Semigroups on Spaces of Measures
Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille
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NimbleAI
Meer informatie over dit onderzoeksproject vind je op de Engelstalige pagina.
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Gravitational waves through the cosmic web
The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.
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On the random-matrix theory of Majorana fermions in topological superconductors
The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.
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Samenwerkingspartners
Het Centre for Professional Learning is een netwerkorganisatie. Vanuit een compacte kern werken wij in onze programma’s per thema graag nauw samen met kennisinstellingen, overheidsorganisaties en voor het betreffende thema relevante maatschappelijke organisaties. Een overzicht van onze partners tref…
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Optical cavities and quantum emitters
Optical cavities are useful tools to enhance the interaction between light and matter, which is important to make good quantum emitters. However, it turns out that the cavities themselves (without any quantum emitters) are already interesting objects to study.
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Deep Hanging Out in the Age of the Digital; Contemporary Ways of Doing Online and Offline Ethnography
A brief review essay on some of the work that has been recently published in the emergent field of digital ethnography.
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Stuiterende hydrogelballetjes populair in de media
De verklaring van natuurkundige Scott Waitukaitis voor de gillende en stuiterende hydrogelballetjes is door verschillende media overgenomen. Zo was Waitukaitis te zien op het RTL 4 journaal van maandag 24 juli.
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Bouwen met flexibele blokjes
Op een ogenschijnlijk gewone kubus verschijnt onder druk een patroon van hollingen en bollingen. Er is nu een methode ontwikkeld om zulke 3 dimensionale structuren te ontwerpen en maken met eenvoudige bouwstenen. Publicatie in Nature.
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Piepkleine deeltjes bouwen zelfstandig complexe structuren
Kleinere computerchips, smallere cameraatjes; ze worden steeds moeilijker om te maken. Maar wat als de bouwstenen zichzelf opbouwen? Natuurkundige Daniela Kraft bedacht een methode om deeltjes aan te sturen in samenklonteren. Publicatie in ACS Nano.
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NWO-XS-subsidies voor twee innovatieve onderzoeksprojecten
Twee Leidse onderzoekers van de Faculteit Wiskunde en Natuurwetenschappen hebben een NWO-XS-subsidie ontvangen voor hun onderzoek. Het gaat om veelbelovende, maar ook risicovolle projecten. Macrofagen die bacteriën vangen en dataopslag gemaakt van 2D-materialen vielen bij de jury in de smaak.
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De donkere kant van het universum ophelderen
Het moet er zijn, alleen kunnen we het niet zien: de raadselachtige donkere materie en donkere energie in het heelal. Henk Hoekstra is een van de vele kosmologen die dolgraag, willen weten waar deze substanties precies uit bestaan. Hij kreeg er een Europese onderzoekssubsidie van 1,3 miljoen euro vo…
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Interaction of oxygen and carbon monoxide with Pt(111) at intermediate pressure and temperature: revisiting the fruit fly of surface science
Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink
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Surface-structure dependence of water-related adsorbates on platinum
Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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Bestrijdingsmiddelen en Milieu
The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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The heart of oxygenic photosynthesis illuminated
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Vamping the Stage: Female Voices of Asian Modernities
Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).
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Dormancy in stochastic interacting systems
Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Tuning in to the feedback bassline: revealing the operation of AGNs in galaxy clusters with high-resolution radio observations
Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Political Muslims: Understanding Youth Resistance in a Global Context
An interdisciplinary collection of the best international scholarship on Muslim youth.
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Evert van Nieuwenburg
Wiskunde en Natuurwetenschappen
e.p.l.van.nieuwenburg@liacs.leidenuniv.nl | +31 71 527 5523
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Spin-momentum locking in oxide interfaces and in Weyl semimetals
Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Topics in the arithmetic of del Pezzo and K3 surfaces
Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk
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Risks to Health and the Environment Related to the Use of Lead in Products
The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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X-raying extragalactic gas: warm-hot gas in the EAGLE simulations
I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.
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Helpen autistische jongeren spontaan een onhandige onderzoeker?
Spontaan elkaar helpen, waarom is dit belangrijk? Het is bekend dat elkaar helpen bijdraagt aan een betere sociale band en goede contacten, en vriendschappen bestendigt. In deze studie voerden we een experiment uit waarin de onderzoeker 'per ongeluk' lucifers liet vallen. De meeste tieners hielpen mee…
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Werken bij Wiskunde en Natuurwetenschappen
Werken bij een topfaculteit? Ontdek de vacatures bij Wiskunde en Natuurwetenschappen en solliciteer meteen.
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Vroege signalen voor een goede geestelijke gezondheid tijdens de adolescentie: Emotionele intelligentie is belangrijk
In een longitudinale studie onderzochten Adva Eichengreen en collega's hoe aspecten van emotionele intelligentie de ontwikkeling van de geestelijke gezondheid van adolescenten beïnvloeden. Zo identificeerden ze potentiële waarschuwingssignalen en doelen voor interventieprogramma's.
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Network analysis methods for smart inspection in the transport domain
Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.