1,486 zoekresultaten voor “effects die development” in de Publieke website
-
Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
-
High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
-
‘Defense, diplomacy, development… and disillusions’
De opzet van de Britse en Nederlandse missies in Zuid-Afghanistan werd ingegeven door Westerse vooringenomenheid, in plaats van door een gedegen, open analyse. Tot deze slotsom komt politicologe en majoor Mirjam Grandia in haar promotieonderzoek naar de Britse en Nederlandse besluitvorming rond de missies…
-
Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
-
Above- and belowground interactions in Jacobaea vulgaris: zooming in and zooming out from a plant-soil feedback perspective
In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…
-
Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
-
Plural Medical System in Pirgos and Praitoria for Community Health Development in Rural Crete, Greece
Promotor: Prof.dr. L.J. Slikkerveer
-
Linkages of Sustainability
Exploring linkages between energy and material use and implications for sustainable development.
-
Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
-
Publicatie artikel “Social support at work and at home: Dual-buffering effects in the work-family conflict process”
Dr. Helen Pluut heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Organizational Behavior and Human Decision Processes (OBHDP) in samenwerking met Remus Ilies (National University of Singapore), Petru Curşeu (Open Universiteit en Babeş-Bolyai University) en Yukun Liu (University of Western…
-
Maak kennis met het Brain and Development Research Center
Onderzoeksvragen stellen en beantwoorden via samenwerking en open science.
-
Cities, migration and global interdependence 1350-2000
The research programme Cities, Migration and Global Interdependence 1350-2000 (CMGI) focuses on urbanisation, migration, and economic development in a comparative and global context.
-
Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
-
Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
-
A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
-
Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
-
George Miley
Wiskunde en Natuurwetenschappen
miley@strw.leidenuniv.nl | +31 71 527 5849
-
Jennifer Anderson
Wiskunde en Natuurwetenschappen
j.a.anderson@cml.leidenuniv.nl | +31 71 527 2727
-
Tales Yamamoto
Wiskunde en Natuurwetenschappen
t.m.yamamoto@cml.leidenuniv.nl | +31 71 527 2727
-
Measuring sustainability: an elaboration and application of the system of environmental-economic accounting for Indonesia
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
-
Yisheng Development gaat entreegebied Bio Science Park ontwikkelen
Yisheng Development gaat het nieuwe entreegebied van het Leiden Bio Science Park vorm geven. De Universiteit Leiden en de gemeente Leiden hebben gekozen voor de Amstelveense projectontwikkelaar, die een duurzaam ontwerp voor een levendige campus voorstelde. Het ontwerp combineert wonen, werken en le…
-
Universiteit Leiden tekent strategische samenwerking met Asian Development Bank
De Universiteit Leiden gaat een strategische samenwerking aan met de regionale ontwikkelingsbank Asian Development Bank. Voorzitter van het College van Bestuur Annetje Ottow ondertekende op 27 april in Manilla de intentieverklaring voor deze unieke samenwerking.
-
Imaging polarimetry for the characterisation of exoplanets and protoplanetary discs. Scientific and technical challenges
Promotor: Prof.dr. C.U. Keller
-
Universiteit Leiden breidt samenwerking met de Asian Development Bank verder uit
De Universiteit Leiden gaat verdere activiteiten met de Asian Development Bank (ADB) opzetten.
-
Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
-
Afdeling Environmental Biology (CML-EB)
De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.
-
Biophysical feedbacks between seagrasses and hydrodynamics in relation to grazing, water quality and spatial heterogeneity
Consequences for sediment stability and seston trapping
-
Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
-
Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
-
Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
-
Aria of the Dutch North Sea
Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn
-
Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
-
Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
-
Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
-
Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
-
Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
-
PhD Candidate in Economics (0.8-1.0 fte)
Rechtsgeleerdheid
-
Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces
Promotor: Prof.dr. G.J. Kroes
-
PhD candidate in Statistics and Pharmacometrics
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
-
resilience: Individual differences in genetic and environmental effects on brain development
Promotie
-
Formative Assessments and Teacher Professional Learning
Hoe kan formatieve assessment worden ingezet om het leren van docenten te bevorderen? Dit boek bevat diverse onderzoeken naar professionaliseringsaanpakken en cursussen waarin formatieve assessment wordt aangewend met het oog op het leren van docenten.
-
Derde jaarlijkse ‘Law and Development Research Network’-conferentie 19 t/m 21 september 2018
Van 19 t/m 21 september werd de derde jaarlijkse ‘Law and Development Research Network’-conferentie gehouden in het Museum Volkenkunde in Leiden.
-
Life Cycle Assessment of Nanomaterials and Risk Assessment.
What is the environmental impact, the human health impact and the life cycle and production costs of the lab, pilot and commercial diffusion of nanowires and nanowire-based photovoltaic technologies?
-
Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
-
Ginsenosides as selective glucocorticoid drugs: agonists, antagonists, and prodrugs
Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…
-
Leefklimaat in Nederlandse penitentiaire inrichtingen
Binnen de Life in Custody Study wordt grootschalig onderzoek gedaan naar het leefklimaat in Nederlandse penitentiaire inrichtingen (PI’s).
-
Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
-
Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
-
The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
-
Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…