Promotor: Prof.dr. T.H.W. Bäck

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

A new publication on changes in the relationship between news and their public in Chile

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

This thesis applies data mining in commercial settings in the telecommunications industry.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: Prof.dr. M. Ubbink

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Promotor: C.J. ten Cate

Promotor: J. Zaanen

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Promotor: A. Kros

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: Prof.dr. W.T.F. den Hollander

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

A brief review essay on some of the work that has been recently published in the emergent field of digital ethnography.

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Since its beginnings, Leiden University has been home to scholars with a broad and diverse expertise in the histories, languages, literatures and material cultures relevant to the study of Jews and Judaism from antiquity to modern times.

The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.

Vanuit twaalf studio’s in Leiden en Den Haag zijn tijdens de Online Master Open Dagen presentaties gegeven, waar geïnteresseerde studenten alles te weten kwamen over hun toekomstige studie.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Promotor: Prof.dr. G.J. Kroes

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Creating a framework to assess the sustainability of fish farms which will set sustainability standards and give consumers information about the the sustainability and safety of their seafood.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.