1,087 zoekresultaten voor “have step” in de Publieke website
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Creative writing (English spoken)
Kunst en vrije tijd, Kunst en vrije tijd
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PhD candidate, Feature-based machine learning for precision diagnosis of neuromuscular diseases
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Modeling interstellar bubbles: near and far
Promotor: Prof. dr. A.G.G.M. Tielens
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Towards superconducting spintronics with RuO2 and CrO2 nanowires
CrO2, a half-metal ferromagnet, has shown great promise for superconducting spintronics applications for nearly two decades.
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Translational Symmetry Breaking in Holographic Strange Metals
In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality.
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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The characteristics of galaxies with powerful radio jets
Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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MA International Relations Online Q&A
Studievoorlichting
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Aspects of the analysis of cell imagery: from shape to understanding
In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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The Monetary Valuation of Water-related Ecosystem Services
While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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The spin evolution of accreting and radio pulsars in binary systems
Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.
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Isotopes and the characterization of extrasolar planets
Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.
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Prosecutorial Discretion in International Criminal Justice
Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.
- Summer School: "Manuscript Studies: Codicology and Digital Techniques" (5 ECTS)
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Measuring gold molecular gas across cosmic time
Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…
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Full Professor (Universitair Hoogleraar) of International Relations
Geesteswetenschappen
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Assembling anisotropic colloidal building blocks
This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Non-take-up of social support and the implications for social policies
This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.
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Smoothly breaking unitarity : studying spontaneous collapse using two entangled, tuneable, coherent amplifiers
The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.
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On hard real-time scheduling of cyclo-static dataflow and its application in system-level design
Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Mononuclear spin-transition materials based on the bapbpy scaffold
Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet
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Deepening the uncertainty dimension of environmental Life Cycle Assessment: addressing choice, future and interpretation uncertainties.
LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.
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Interstellar Catalysts and the PAH universe
Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.
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Cool little kids
De effectiviteit van een vroeg interventieprogramma voor angstige peuters in Nederland
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Software developments in automated structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu
- Onderzoeksprojecten
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Benoeming op hoog niveau voor EIBL-alumnus Martin Richardson
Martin Richardson, die in 1997 afstudeerde aan het toenmalige Leiden LLM Programme in European Community Law (nu: Leiden Adv LLM European and International Business Law, EIBL), is onlangs benoemd tot Senator van het College of Justice in Schotland. Dat betekent dat hij nu rechter is van de hoogste civiele…
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
- Contact
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Leiden Law students are looking forward to the lawyer of the future
As Leiden Law students, we are now in the digital age, 'where we believe law and technology should go together.' After all, for us, it is important to look beyond trodden paths of established legal knowledge. The books on law and case law surely will not be sufficient for the lawyer of the future. That…
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Molecular mystery in space
The space between the stars isn't simply a void; it also contains substances such as methanol and carbon dioxide. So far, chemical theories have been unable to explain how these substances originate under circumstances that should make it impossible. Fedor Goumans has been awarded a Veni subsidy to…
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Do we have a standard model of cosmology?
Lezing, Oort lecture
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Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates
We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…