The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Nature, nurture and neural mechanisms of social emotion regulation in childhood

Creating information portals for support of European environmental policy.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Sterrewacht Leiden is het sterrenkundig instituut van de Faculteit der Wiskunde en Natuurwetenschappen van de Universiteit Leiden.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Promotor: Prof.dr. G.J. Kroes

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Creating a framework to assess the sustainability of fish farms which will set sustainability standards and give consumers information about the the sustainability and safety of their seafood.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Possible improvements for the assessment of abiotic depletion in LCA.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

De in de introductie geschetste ontwikkelingen leiden ertoe dat huishoudens meer verantwoordelijk gaan dragen voor sociale risico’s, meer zelf moeten plannen, over een langere periode en onder meer onzekerheid.Dit geldt niet alleen in Nederland, maar ook in andere westerse landen. Dit leidt tot de onderstaande…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Het boek 'Invisible agents' van Nadine Akkerman is opgepikt door verschillende media in binnen- en buitenland. Bekijk o.a. vijfsterrenrecensies in landelijke kranten als The Times en The Sunday Telegraph.

Alumni-activiteit, Lezing

Empirisch en experimenteel onderzoek dat zich richt op literair, juridisch, medisch en audiovisueel vertalen.

Lezing, Studium Generale

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?