519 zoekresultaten voor “molecular genetics” in de Publieke website
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Unconventional fabrication of 2D nanostructures and graphene edges
In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.
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Functional analysis of genetic variants in PALB2 and CHEK2
Promotie
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Measuring Cold Molecular Gas Across Cosmic Time
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
- My DNA and the community: what is the future?
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Deadlines voor aanmelden
Check hieronder de aanmelddeadlines voor de opleiding Molecular Science and Technology.
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Wil Tamis
Wiskunde en Natuurwetenschappen
tamis@cml.leidenuniv.nl | +31 71 527 2727
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Kat Stewart
Wiskunde en Natuurwetenschappen
k.a.stewart@cml.leidenuniv.nl | +31 71 527 2727
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Genetic and clinical pharmacology studies in GBA1-associated Parkinson's disease
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Using functional genetic screens to understand and overcome PARP inhibitor resistance
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Molecular inheritance from cloud to disk
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Toelatingseisen
Check de volgende toelatingseisen voordat jij je aanmeldt voor de opleiding Molecular Science and Technology.
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Orion's Dragon and Other Stories
Stellar feedback is a crucial ingredient in the evolution of galaxies.
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Towards in-cell structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
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Towards Optical Detection of a Single Electron
Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Orchid mycorrhizal interactions: evolutionary trajectories and ecological variations
The mycorrhizal symbiosis is among the most widespread species interactions on Earth. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries.
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Protoplanetary disk anatomy: examining the structure and chemistry of planetary birthplaces with simple molecules
This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.
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Unveiling protostellar disk formation around low-mass stars
Promotor: Prof.dr. E.F. van Dishoeck
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Bridging the gap between physics and chemistry in early stages of star formation
A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.
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Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
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Genetic and clinical aspects of inherited syndromes associated with adenomatous polyposis
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Ecological functioning of bacterial chitinases in soil
Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Dynamic organization of bacterial chromatin by DNA bridging proteins
Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Comparative biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Genetische syndromen
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Systematic, phylogenetic and pollination studies of Specklinia (Orchidaceae)
Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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The evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Studies on molecular basics of metabolic syndrome in zebrafish
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Characterization of DNA-replication proteins and their molecular mechanisms
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Contextual glucocorticoid signaling in-vivo: A molecular perspective
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
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