282 zoekresultaten voor “neurodegenerative disease” in de Publieke website
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Urbanization in Indonesia and Its Impact on Non-communicable Diseases
Promotie
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Aortic valve disease: multimodality imaging for risk stratification and evaluation of therapy
Promotie
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in acute myocardial infarction and the assessment of valvular heart disease
Promotie
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
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Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
Promotie
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Genetic and clinical pharmacology studies in GBA1-associated Parkinson's disease
Promotie
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Multi-modality imaging in ischemic heart disease, arrhythmia and cardiac-mechanics
Promotie
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Based Pituitary Care, implementing Value Based Health Care in a rare disease
Promotie
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Optimising neonatal management of haemolytic disease of the foetus and newborn
Promotie
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closer look: Non-invasive tools for in-depth characterisation of vulvar diseases
Promotie
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Therapeutic neovascularization for peripheral arterial disease; in vivo models and potential therapeutic factors
Promotie
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to predictive modeling: cerebrovascular events and chronic kidney disease
Promotie
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Specifiek eiwit in de hoofdrol bij ziekte van Parkinson
Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…
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elderly in clinical trials: how to define preclinical Alzheimer’s Disease for clinical trial participation
Promotie
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Remodeling, Myocardial Function and Risk Stratification in Cardiovascular Disease
Promotie
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autoantibody-positive and autoantibody- negative rheumatoid arthritis during the disease course
Promotie
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microbiota transplantation and dietary interventions in Inflammatory Bowel Disease; efficacy and challenges for the future
Promotie
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A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
Promotie
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Multimodality Imaging in Coronary Artery Disease: Plaque Characterization, Computational Haemodynamic Simulation and Risk Stratification
Promotie
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Is thyroid status a common denominator of age-related disease?
Promotie
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Instituut Biologie Leiden
De natuur is een onuitputtelijke inspiratiebron voor de wetenschappers van het Instituut Biologie Leiden (IBL). Vanuit het streven naar fundamenteel begrip van de natuur zoeken zij naar oplossingen op het gebied van gezondheid en behoud van de biodiversiteit. Het thema van het instituut is ‘Harnessing…
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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LUMC-hoogleraar krijgt prijs op Zeldzame Ziektendag
Prof. Judith Bovée kreeg zaterdag een prijs uitgereikt op Zeldzame Ziektendag. De prijs is een blijk van waardering vanuit de gezamenlijke patiëntenverenigingen voor haar wetenschappelijk en diagnostisch werk op het gebied van zeldzame bottumoren.
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Fulltime programme
Het schema hieronder geeft het curriculum weer van het eenjarige fulltime programma van de master Health, Ageing and Society in collegejaar 2024-2025.
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Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.