337 zoekresultaten voor “neurodegenerative disease” in de Publieke website
-
Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
-
Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
-
Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
-
System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
-
Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
-
Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
-
Lecture Series | Novel approaches to delay ageing and age-related diseases
Lezing, Lezing onderdeel van serie
-
IBL coördineert project voor nieuwe medicijnen uit biodiversiteit van de zee
Gilles van Wezel van het Instituut Biologie Leiden gaat een Europees consortium leiden om nieuwe medicijnen en ziekte-onderdrukkende microben te vinden, met behoud van biodiversiteit. Er wordt gekeken naar het nog grotendeels onbekende potentieel van in de zee levende micro-organismen.
-
Nieuw project om ziekte van Alzheimer te bestuderen
Onderzoekers van de Universiteit Leiden gaan een nieuwe manier ontwikkelen om de biomarkers van de ziekte van Alzheimer te bestuderen. De aanpak focust zich op de moleculaire boodschappers van de cellen. Het project, geleid door Thomas Hankemeier en gecoördineerd door Yuliya Shakalisava (Leiden Academic…
-
Deze elf Leidse bètaonderzoekers behoren tot de meest geciteerden ter wereld
Elf onderzoekers van de faculteit Wiskunde en Natuurwetenschappen staan op de 2021 Highly Cited Researchers-lijst van Clarivate Analytics. Slechts 0,1 procent van de wereldwijde onderzoekers komt in deze lijst voor, waarmee ze dus letterlijk één uit duizend zijn.
-
Urbanization in Indonesia and Its Impact on Non-communicable Diseases
Promotie
-
Aortic valve disease: multimodality imaging for risk stratification and evaluation of therapy
Promotie
-
in acute myocardial infarction and the assessment of valvular heart disease
Promotie
-
Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
-
Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
Promotie
-
Genetic and clinical pharmacology studies in GBA1-associated Parkinson's disease
Promotie
-
Multi-modality imaging in ischemic heart disease, arrhythmia and cardiac-mechanics
Promotie
-
Based Pituitary Care, implementing Value Based Health Care in a rare disease
Promotie
-
Optimising neonatal management of haemolytic disease of the foetus and newborn
Promotie
-
closer look: Non-invasive tools for in-depth characterisation of vulvar diseases
Promotie
-
miniaturised assays for structure-resolved lipidomics in metabolic disease
Promotie
-
pharmacology of antimicrobials, towards optimized treatment of infectious diseases in hospitalized patients
Promotie
-
Therapeutic neovascularization for peripheral arterial disease; in vivo models and potential therapeutic factors
Promotie
-
to predictive modeling: cerebrovascular events and chronic kidney disease
Promotie
-
elderly in clinical trials: how to define preclinical Alzheimer’s Disease for clinical trial participation
Promotie
-
Remodeling, Myocardial Function and Risk Stratification in Cardiovascular Disease
Promotie
-
autoantibody-positive and autoantibody- negative rheumatoid arthritis during the disease course
Promotie
-
microbiota transplantation and dietary interventions in Inflammatory Bowel Disease; efficacy and challenges for the future
Promotie
-
A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
Promotie
-
Unraveling the broad NOTCH3-associated small vessel disease spectrum: from CADASIL to non-penetrance
Promotie
-
Non-invasive biomarkers for inflammatory skin diseases: towards systems dermatology
Promotie
-
Multimodality Imaging in Coronary Artery Disease: Plaque Characterization, Computational Haemodynamic Simulation and Risk Stratification
Promotie
-
Specifiek eiwit in de hoofdrol bij ziekte van Parkinson
Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…
-
Instituut Biologie Leiden
De natuur is een onuitputtelijke inspiratiebron voor de wetenschappers van het Instituut Biologie Leiden (IBL). Vanuit het streven naar fundamenteel begrip van de natuur zoeken zij naar oplossingen op het gebied van gezondheid en behoud van de biodiversiteit. Het thema van het instituut is ‘Harnessing…
-
The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
-
Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
-
Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
-
Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
-
PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
-
Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
-
Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
-
The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
-
1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
-
Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
-
Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
-
Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
-
Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
-
Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
-
Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
-
Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea