758 zoekresultaten voor “rights to self-determination” in de Publieke website
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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A molecular journey : tales of sublimating ices from hot cores to comets
The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.
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Macro-level assessment of environmental implications of changes to circularity
How to ensure the environmental and economic benefits of circularity transition at macro-scale?
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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From Star-formation to Recombination: Expanding our View of the Radio-Recombination-Line Universe
The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Cleared for take-off, Game-based learning to prepare airline pilots for critical situations
Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.
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Exposed to events that never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Computational aspects of class group actions and applications to post-quantum cryptography
Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…
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homogeneous catalysts for the selective conversion of levulinic acid to caprolactam
Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Soil and crop management options to improve nitrogen cycling on dairy farms on peat soil
The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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approach towards stability of delay differential equations with applications to neural networks
Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans
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Safe anytime-valid inference: from theory to implementation in psychiatry research
Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Pushing the characterization of exoplanet atmospheres down to temperate rocky planets in the era of JWST
One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.
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From molecules to monitoring: Integrating genetic tools into freshwater quality assessments
Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.
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ECOLE: Experience-based COmputation: Learning to optimisE
Onderzoekers van het Leiden Institute of Advanced Computer Science (LIACS) gaan een opleidingsprogramma ontwikkelen voor de volgende generatie van beginnende onderzoekers (ESR's). Gedurende een vierjarig project zullen zij worden opgeleid om industriële uitdagingen op een holistische manier te benaderen…
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Proving discriminatory violence at the European Court of Human Rights
Op dinsdag 23 mei 2017 verdedigt Jasmina Mackic haar proefschrift ‘Proving discriminatory violence at the European Court of Human Rights’. De verdediging begint om 15.00 uur, in het Academiegebouw van de Universiteit Leiden, Rapenburg 73. De promotor is vice-decaan en hoogleraar internationaal publiekrecht…
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A culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.
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Politics, Culture and National Identities, 1789 to the Present (research) (MA)
De specialisatie Politics, Culture and National Identities, 1789 to the Present (research) van de Universiteit Leiden brengt je in de voorhoede van de nieuwe benadering van de manier waarop in Europa politiek en identiteit worden opgevat.
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A well-established harmony in chaos: from isolated galaxies to galaxy clusters
The origin and evolution of galaxies are closely linked to many different physical phenomena.
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Adding fuel to the conflict : how gas reserves complicate the Cyprus question
In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.
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X-ray spectroscopy of interstellar dust: from the laboratory to the Galaxy
In this thesis, we present new laboratory data of interstellar dust analogues.
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Mining the kinematics of discs to hunt for planets in formation
Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Squaramide-based supramolecular polymers : from self-assembly to in vivo application
The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.
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From the root of variation: A metabolomics perspective to plant soil-feedback
By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.
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Studying dark matter using weak gravitational lensing : from galaxies to the cosmic web
Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).
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Development of new chemical tools to study the cannabinoid receptor type 2
The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.
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Personalised pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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Linking soil microbial community dynamics to N2O emission after bioenergy residue amendments
Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Irene Hadiprayitno
Faculteit der Geesteswetenschappen
i.hadiprayitno@hum.leidenuniv.nl | +31 71 527 7402
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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the greening Arctic: compositional and functional shifts in response to climatic changes
Promotor: E.F. Smets Co-promotor: J. Geml
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Applications of Natural Deep Eutectic Solvents to Extraction and Preservation of Biomolecules
The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.
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Self-assembly of flexible and rigid structures: from colloidal molecules to lattices
Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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The flexible listener: exploring zebra finch sensitivity to spectral and temporal sound features
Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…
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Observing what cannot be observed: computational electrochemistry from carbon to hydrogen
In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame