1,502 zoekresultaten voor “role families” in de Publieke website
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Structure dependence of molecular reactions on surfaces
The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Mechanical metamaterials: nonlinear beams and excess zero modes
Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.
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Forgotten Lineages. Afterlives of Dutch Slavery in the Indian Ocean World
Forgotten Lineages explores the paths through which generations of formally enslaved and their descendants gradually forgot their past of enslavement under Dutch and British imperial rule and became local subjects in Sri Lanka and South Africa. It explores why and how forgetting rather than memory became…
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A Society in Distress, The Role of Museums
Afscheidscollege
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Modelling the role of mycorrhizal associations in soil carbon cycling
Promotie
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Punten tellen op oppervlakken
van Luijk
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Essentiality of conserved amino acid residues in β-lactamase
Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.
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Metals in the diffuse gas around high-redshift galaxies
Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)
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Electrocatalytic reduction of CO2 and nitrate on immobilized metal porphyrins
M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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De Kolyvan-Voskresensk Fabrieken en de Russische Integratie van Zuid-Siberië, 1725-1783
How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?
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Gert Oostindie in verschillende media over onderzoek koloniaal verleden koningshuis
De koning heeft opdracht gegeven om het koloniale verleden van het koningshuis te laten onderzoeken. De commissie wordt voorgezeten door emeritus hoogleraar Gert Oostindie, die in verschillende media reageert op dit nieuws.
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The Invisible History of the United Nations and the Global South - INVISIHIST
The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…
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Koopmanszoon Michiel Heusch op Italiëreis. Brieven van het thuisfront (1664-1665)
Het boek behandelt de achtergronden van de Hamburgse migrantenfamilie Heusch, oorspronkelijk afkomstig uit Antwerpen, en de intrigerende taalcontactsituatie van de in het Nederlands geschreven brieven. Ook bevat het een uitgave van de brieven met inleiding en toelichting.
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Kanker en erfelijkheid
Sommige mensen hebben aanleg om kanker te krijgen. Al bij de geboorte kunnen er mutaties in het erfelijk materiaal zitten die de kans op het krijgen van kanker verhogen. Onderzoekers nemen deze mutaties onder de loep om meer te weten te komen over hoe kanker ontstaat.
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'De invloed van 30 jaar Kinderrechtenverdrag in Nederland' aangeboden aan Kinderombudsvrouw
Op 8 september werd het nieuwe boek van de afdeling Jeugdrecht, ’De invloed van 30 jaar Kinderrechtenverdrag in Nederland’, aangeboden aan Kinderombudsvrouw Margrite Kalverboer tijdens de officiële opening van de masteropleiding Jeugdrecht 2020/21 in Leiden.
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Amerikaans buitenlands beleid en liberalisme
The NWO-funded Vidi project “American foreign policy and liberalism” challenges the idea that the United States has created and sustained a “liberal international order” since World War II. It instead explores the ways in which illiberal ideologies – such as those underpinning racial hierarchy at home…
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Ubar Kampung
The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…
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Safety First
Safety First. How local processes of securitization have affected the position and role of Dutch mayors. Nederlandse burgemeesters super-netwerkers. Nederlandse burgemeesters zien zich anno 2014 geconfronteerd met een grote variëteit aan nieuwe veiligheidsvraagstukken, waaronder radicalisering, loverboys…
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Het Groothertogdom Litouwen en de Gouden Horde
Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?
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Antoni van Leeuwenhoek en de familie Huygens
Lezing, Studium Generale
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Evolutionary diversification of Nepenthes (Nepenthaceae)
Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes
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Satellite remote sensing of plant functional diversity
Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Cyclophellitol and its derivatives: synthesis and application as beta-glycosidase inhibitors
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Exploring structure dependencies of gas-surface interactions with curved single crystals
Curved single crystals provide variable, but well-defined surface structures.
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On shape and elasticity: bio-sheets, curved crystals, and odd droplets
Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Beyond science and art: The role of intuition
Cursus, Workshop
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Mishandeling pleegmeisje uit Vlaardingen legt problemen jeugdzorg bloot
Maanden nadat de zaak van het mishandelde pleegmeisje uit Vlaardingen aan het licht kwam, blijven er veel vragen open. Waarom werd er niet geluisterd naar het kind? Mariëlle Bruning, hoogleraar jeugdrecht, sprak erover met NOS en NPO Radio 1.
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Kinderen zijn tijdens echtscheidingen bang om het 'verkeerde' te zeggen tegen rechters
Houdt de rechtbank tijdens een echtscheiding wel voldoende rekening met de ervaringen van een kind? Onderzoek van Villa Pinedo toont aan dat kinderen vaak vrezen het verkeerde te zeggen tegen rechters. Hoogleraar jeugdrecht Mariëlle Bruning praatte erover met NRC.
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Organisational & Entrepreneurial Behaviour
De onderzoeksgroep Organizational & Entrepreneurial Behavior onderzoekt het gedrag van individuen en groepen die in organisaties werken, organisaties starten, of organisaties leiden, met als doel om organisatorische praktijken te informeren. Door zich te concentreren op het gedrag van (groepen) werknemers,…
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slotconferentie - Omgaan met kinderen uit gewelddadige extremistische families
Congres/symposium
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Patterns of coral species richness and reef connectivity in Malaysia
Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema
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Measures and Matching for Number Systems
This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.
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Computer Mediated Communicatie
Toen de corona-pandemie uitbrak, veranderde er ineens heel veel in onze dagelijkse communicatie. We konden familie niet meer bezoeken en de scholen sloten. Door de coronamaatregelen communiceerden we veel meer digitaal met familie, vrienden/vriendinnen en leraren of klasgenoten. Dat was voor iedereen…
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Koopmanszoon Michiel Heusch op Italiëreis: Brieven van het thuisfront (1664-1665)
Inzichten in opmerkelijke taalverschijnselen en gedetailleerde prijs- en handelsinformatie maken dit boek interessant voor zowel taalkundig geïnteresseerden als belangstellenden in sociale en economische geschiedenis.
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Unconditionally secure cryptographic protocols from coding-theoretic primitives
This dissertation presents new cryptographic protocols, which can be divided into two families.
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Split Jacobians and Lower Bounds on Heights
This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.