Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

De Raad van State heeft geschiedenis geschreven met zijn verrassende uitspraak vorige maand inzake de gaswinning in Groningen. Dat stelde de Groningse hoogleraar Herman Bröring dinsdag tijdens een gastcollege aan de Universiteit Leiden. De Raad van State vernietigde een besluit van minister Kamp. Een…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Van 26 t/m 30 juni 2017 organiseert de afdeling Staats- en Bestuursrecht van de Universiteit Leiden een zomercursus over de Europeanisering van het nationaal bestuursrecht in de lidstaten van de Europese Unie.

Hoe en in welke mate beïnvloedt AI de vertegenwoordiging van burgers in openbare dienstverlening en interacties tussen staat en burger?

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotores: H. Schiessel, G.T. Barkema

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Oratie

De Raad van State heeft een programma van reflectie opgesteld, waarmee de hoogste bestuursrechter zijn aandeel in de kindertoeslagaffaire wil evalueren om lessen uit de affaire te kunnen trekken.

On 12 September 2019, Judge Chile Eboe-Osuji, President of the International Criminal Court (ICC), delivered a lecture on Customary International Criminal Law and Head of State Immunity to open the academic year for the Advanced LL.M. Programmes in Public International Law & International Dispute Settlement…

Op 14 november organiseerde het Team Strategie & Verbinding van het DG Migratie van het Ministerie van Justitie en Veiligheid de jaarlijks de State of the Art conferentie. De conferentie brengt wetenschappers, beleidsmakers en andere professionals in het migratiedomein bijeen rond belangrijke migratievraagstukken.…

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Per 20 augustus gaat universitair hoofddocent Michiel Tjepkema aan de slag bij de directie Bestuursrechtspraak van de Raad van State. Hij wordt het eerste hoofd van de kennisunit.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Carola Schoor, programmaleider Public Affairs bij het Centre for Professional Learning (CPL), reflecteert op Politico op de State of the European Union speech door Ursula von der Leyen, president van de Europese Commissie.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…

Lezing, NGL-lezing

Wat kunnen publieke leiders leren van crisismanagement? In de tweede Leiden Leadership Lunch in de serie ‘Leiderschapskansen in tijden van crisis’ deelden Dr. Jaap van Lakerveld en Dr. Jeroen Wolbers – experts op het gebied van crisismanagement – enkele inzichten uit het recent gepubliceerde rapport…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotie

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

‘Anyone who has not been shocked by quantum mechanics has not understood it.’ Verwonder jij je ook niet dagelijks over kwantummechanica en de state of being van atomen? Volgens natuurkundige Niels Bohr, een van de grondleggers van de kwantummechanica, begrijp je dan gewoon nog niet genoeg van dit bijzondere…

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Rogier Kegge, universitair docent bestuursrecht en omgevingsrecht, vertelt in Nieuwsuur over de verstrekkende gevolgen van de uitspraak van de Afdeling Bestuursrechtspraak van de Raad van State van 29 mei 2019 (ECLI:NL:RVS:2019:1603) over het Programma Aanpak Stikstof.

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.