Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

In this thesis, we present new laboratory data of interstellar dust analogues.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Prof.dr. M.A.G.J. Orrit

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Het sociaal recht is voortdurend in beweging. Tegelijkertijd gaat het recht van de werkende mens om fundamentele zaken, die onveranderlijk van gewicht en waarde zijn. Het onderzoek van de afdeling Sociaal recht richt zich zowel op de (voortdurende) veranderingen in het arbeidsrecht en het sociaalzekerheidsrecht,…

De afgelopen decennia zijn financiële ondernemingen zoals banken, verzekeraars, pensioenfondsen en beleggingsondernemingen geconfronteerd met substantieel indringender regelgeving. Dit geldt zeker voor de EU, waar Brexit bovendien de dynamiek van Europese financiële regelgeving heeft veranderd. Het…

Op donderdag 8 december is Fred van Haasteren gepromoveerd op zijn proefschrift ‘Fatsoenlijke flexibiliteit – De invloed van ILO-conventie 181 en de regelgeving omtrent uitzendarbeid’, in het Academiegebouw van de Universiteit Leiden. Promotor was hoogleraar internationaal arbeidsrecht Paul van der…

Drie grote actuele thema’s in economisch beleid vormen de rode draad door de opleiding: ongelijkheid, klimaat en technologisering.

Dr. Moritz Jesse, Europa Instituut van de Leidse rechtenfaculteit, heeft een Jean Monnet-leerstoel gekregen. Vanaf november 2023 zal Moritz cursussen op bachelor- en masterniveau geven als onderdeel van zijn project ‘Migration, Integration, Non-Discrimination in the EU’ [MIND-EU]. Vanaf volgend jaar…

Legitiem belangen vertegenwoordigen en afwegen, hoe doe je dat? In opdracht van het Ministerie van Binnenlandse zaken ontwikkelden Caelesta Braun en Bert Fraussen een Afwegingskader Legitieme Belangenvertegenwoordiging. Het hoe, waarom en nut van een weloverwogen lobbyregister leggen de onderzoekers…

In opdracht van het Ministerie van Justitie gaat eLaw, Centrum voor Recht en Digitale Technologie, de bescherming van persoonsgegevens in verschillende EU-landen vergelijken. Is Nederland koploper, middenmoter of achterhoedespeler? Die vraag moet worden beantwoord alvorens de Tweede Kamer kan beslissen…

D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

Jan de Keijser is per 1 januari 2018 benoemd als lid van het College van het Nederlands Register Gerechtelijk Deskundigen (NRGD).

Op 15 september sprak Armin Cuyvers over Brexit bij de De Academie voor Wetgeving, het opleidingsinstituut van de Rijksoverheid op het terrein van wet- en regelgeving.

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

Overzicht van economische vakken per opleiding, zoals aangeboden door de Afdeling Economie.

De Belastingdienst houdt intern beleid over de uitleg van belastingwetten buiten de openbaarheid. Daar moet een einde aan komen, vindt universitair docent Martijn Nouwen.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

A recent study on reintroduced tigers in Panna Tiger Reserve in India reveals that risks from tigers increased more because of human behaviour and people's livestock husbandry practices.

A linguistic prehistory of the Tarim Basin in Northwest China

De wereld is vol oorlog, en geen oorlog is zonder doden. Wat gebeurt er met de lichamen van dodelijke slachtoffers van oorlogsgeweld? De winnaar van de facultaire Jongbloed scriptieprijs 2015 is Welmoet Wels (Internationaal Publiek Recht). Haar scriptie Dead body management in armed conflict: paradoxes…

Dit boek maakt deel uit van een reeks waarin een Restatement (systematische herformulering van gemeenschappelijke normen) van het arbeidsrecht in Europa wordt ontwikkeld. Het tweede deel kijkt naar atypische arbeidsrelaties in Europa.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.