This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Franc Weerwind studeerde tussen 1986 en 1992 bestuurskunde aan de Universiteit Leiden. Nu is de heer Weerwind burgemeester van de gemeente Almere. De redactie van de Leidraad (alumnimagazine Universiteit Leiden) sprak met hem in het kader van de 'Werkplek van' rubriek die in iedere editie terug komt…

Is de wereld om ons heen luidruchtiger geworden of zijn we inmiddels gewend aan oordopjes en koptelefoons?

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

In this thesis, we present new laboratory data of interstellar dust analogues.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Prof.dr. M.A.G.J. Orrit

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Ontwikkeling van effectieve VR-training voor internationaal recht van gewapende conflicten (ILAC)

Op 26 en 27 september namen Eduard Fosch-Villaronga, Carlotta Rigotti, Mohammed Raiz Shaffique, Marie Schwed-Shenker en Antoni Mut Piña deel aan de derde editie van Lawtomation Days aan de IE University in Madrid.

D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

De Universiteit Leiden is gestart met activiteitgericht huisvesten: het idee van voor elke activiteit een passende ruimte maken. Zo wordt medewerkers een werkplek gegeven voor hun verschillende werkzaamheden gedurende de dag.

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh