1,306 zoekresultaten voor “been analysis” in de Publieke website
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Peter Burger en Suzan Verberne in de Volkskrant over QAnon en taalkunde
Twee teams met taalwetenschappers deden onafhankelijk van elkaar onderzoek naar de identiteit van ‘Q’, de persoon van wie wordt verondersteld dat die de complottheorie heeft verspreid. Beide studies lijken te wijzen naar hetzelfde duo.
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Dit schrijven de media over Nederlandse primeur in dampkring exoplaneet
Woensdag 14 juli publiceerden Nederlandse astronomen een primeur in vakblad Nature. Het was hen als eersten ter wereld gelukt om isotopen te ontwaren in de damkring van een exoplaneet. Een ontdekking die ons meer kan leren over het ontstaan van planeten. Verschillende media schreven over de bijzondere…
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Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Transport coefficients and low energy excitations of a strongly interacting holographic fluid
In this thesis, classes of strongly interacting quantum field theories, have been studied.
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Lines in the sand: behaviour of self-organised vegetation patterns in dryland ecosystems
Vast, often populated, areas in dryland ecosystems face the dangers of desertification.
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Pesticides Atlas overhauled in line with European Framework Directive on Water
The Dutch atlas with pesticides concentrations in surface waters have been overhauled. This new, free accessible, website is in line with the European Framework Directive on Water (In Dutch: KRW).
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Inferno Worlds
A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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Bacterial glycomimetics: synthesis and applications
This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.
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Recommended weighting methods
The project falls in the context of the EU Thematic Strategy on the Sustainable Use of Natural Resources (COM(2005)670). The Institute for Environment and Resources (IES) of the Joint Research Centre (JRC) has developed three sets of decoupling indicators. Such indicators require the definition of a…
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BIOMOT: Motivational strength of ecosystem services and alternative ways to express the value of biodiversity
Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?
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Environmental Impacts of Diet Changes
Evaluating the environmental consequences of diet changes in the European Union.
- Foundations of Research – 1: Sources & Methods of Source Analysis (3/5 ECTS)
- Foundations of Research – 1: Sources & Methods of Source Analysis (3 ECTS)
- Foundations of Research - 1: Sources & Methods of Source Analysis (3 ECTS)
- Foundations of Research - 1: Sources & Methods of Source Analysis (3 ECTS)
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Sneller schaatsen dankzij data science
Veel Nederlandse schaatsers en voetballers behoren tot de absolute wereldtop. Toch kunnen ze dankzij slimme statistische analyses wellicht nóg een beetje beter worden. De Universiteit Leiden werkt er samen met Delft en Amsterdam aan.
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Alastair Reed over het voorkomen van gewelddadig extremisme bij herstel na belegering
Alastair Reed, universitair docent bij het Institute of Security and Global Affairs (ISGA), is geïnterviewd door Devex, het mediaplatform voor de wereldwijde ontwikkelingsgemeenschap.
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Carbon4PUR | Turning industrial waste gases (mixed CO/CO2 streams) into intermediates for polyurethane plastics for rigid foams/building insulation
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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ALL-IN meta-analysis
Promotie
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…
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Over het Dual PhD Centre
Het Dual PhD Centre bestaat om een bijzondere groep promovendi aan de Universiteit Leiden extra ondersteuning te bieden: de duale promovendi.
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Towards superconducting spintronics with RuO2 and CrO2 nanowires
CrO2, a half-metal ferromagnet, has shown great promise for superconducting spintronics applications for nearly two decades.
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Postmaterialism and Socioeconomic Status Impact in the Chilean Voting Behavior
This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…
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Pyrrole-based photoswitchable anion receptors
The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.
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Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides
The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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X-ray spectroscopy of merging galaxy clusters
This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.
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Exploring Images With Deep Learning for Classification, Retrieval and Synthesis
In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Aggravating matters: accounting for baryons in cosmological analyses
Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.
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Figuring rural development: concepts and cases of land use, sustainability and integrative indicators
Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
- ELS lab meeting – Methodology session on social network analysis
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Explorations of Water Oxidation Catalysis in Explicit Solvent
In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.
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Monsters in the Deep: Using simulations to understand the excess baryonic mass in the centres of high-mass, early-type galaxies
This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.