597 zoekresultaten voor “gene theory” in de Publieke website
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Research in Physics, theoretical (MSc)
Deze master specialisatie behandelt een breed scala aan wetenschappelijke onderwerpen, waaronder High Energy Physics and Particle Cosmology, Theoretical Physics of Life Processes en Condensed Matter Theory.
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Statistical methods for microarray data
Promotores: J.C. van Houwelingen, S.A. van de Geer
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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The Ecology and Evolution of Microbial Warfare in Streptomyces
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Shepherding precision gene editing with CRISPR-Cas9 variants and adenoviral vectors
Promotie
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Shtuka cohomology and special values of Goss L-functions
Assuming everywhere good reduction we generalize the class number formula of Taelman to Drinfeld modules over arbitrary coefficient rings.
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Media Studies (MA)
De masteropleiding Media Studies van de Universiteit Leiden combineert theoriekennis met praktijkervaring om zo een ideale springplank te vormen voor een carrière in de literatuur, film, fotografie of journalistiek.
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Robots die zich inleven in de mens
Om intelligentere en liefst ook sociale robots en computersystemen te bouwen, moet er eerst meer kennis komen over de manier waarop mensen informatie interpreteren. Max van Duijn en Tessa Verhoef doen onderzoek op het snijvlak tussen sociale wetenschap en AI.
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Political discourses and the securitization of democracy in post-1991 Ethiopia
This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.
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Matching, entropy, holes and expansions
In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.
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X-ray spectroscopy of interstellar dust: from the laboratory to the Galaxy
In this thesis, we present new laboratory data of interstellar dust analogues.
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Minor Creative Strategies for a Society in Change
De minor Creative Strategies for a Society in Change (CSSC) legt een verbinding tussen het verkrijgen van inzicht in creatieve maakprocessen en het verkennen van maatschappelijke problematieken die kenmerkend zijn voor onze tijd.
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Gene Networks-based Mechanistic Assessment of Drug-induced Organ Toxicity
Promotie
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Mechanisms and consequences of horizontal gene transfer in cell wall- deficient cells of Kitasatospora viridifaciens
Promotie
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Noisy Patterns: Bridging the gap between stochastics and dynamics
In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…
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On the Galois closure of commutative algebras
Promotores: H.W. Lenstra, B. Erez, Co-promotor: L. Taelman
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Mathematics (MSc)
Deze tweejarige opleiding heeft twee componenten. De eerste is een meer analysegerichte component, met onderwerpen als dynamische systemen, differentiaalvergelijkingen, kansrekening en stochastiek, percolatie of wiskunde in de life sciences. De andere betreft een meer algebra- of meetkundegerichte component,…
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CRB1 gene therapy coming of age: Mechanistic insight and rAAV assays on mouse & human retinal organoid models
Promotie
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species
The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.
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Linking soil microbial community dynamics to N2O emission after bioenergy residue amendments
Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.
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Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Bestuurlijke Aandacht tijdens Politieke Turbulentie
Besluitvormers in de publieke sector opereren te midden van een overvloed aan informatie en onduidelijke politieke doelstellingen. Aandacht is de sine qua non van beleidsvorming: waar aandacht voor is kan geadresseerd worden in beleidsoplossingen; wat over het hoofd gezien wordt niet. Ondanks het belang…
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Tim Verdoes
Faculteit Rechtsgeleerdheid
t.l.m.verdoes@law.leidenuniv.nl | +31 71 527 7753
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Andries Hiskes
Faculteit der Geesteswetenschappen
a.r.hiskes@hum.leidenuniv.nl | +31 71 527 2727
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Ramira van der Meulen
Wiskunde en Natuurwetenschappen
a.van.der.meulen@liacs.leidenuniv.nl | +31 71 527 2727
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Bartolomeus Häussling Löwgren
Wiskunde en Natuurwetenschappen
b.j.p.m.haussling.lowgren@cml.leidenuniv.nl | +31 71 527 2727