In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Promotor: B.van de Water, Co-promotor: L.S.Price

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Many of our department’s staff members are actively involved in the Empirical Legal Studies lab and strive towards publishing impactful empirical legal research.

In dit proefschrift staat het leren van ervaren docenten in een context van samenwerking in interdisciplinaire teams centraal.

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Kunnen landen bij gebrek aan een sterk internationaal kader voor milieubescherming unilateraal optreden om het wereldwijde milieu te beschermen?

Wereldwijd hebben miljoenen kinderen te maken met ziektes die relatief makkelijk te voorkomen zijn. Sarah Spronk onderzocht de vraag welke prioriteiten voortvloeien uit het recht op gezondheid van kinderen om vervolgens kindgerichte gezondheidszorg te kunnen vormgeven.

Niels van Willigen (Instituut Politieke Wetenschap, Universiteit Leiden) plaatst de Nederlandse deelname aan VN vredesmissies in een historische context. Hij bekijkt de redenen voor een afname van de Nederlandse inbreng na 1990 en verkent de obstakels en mogelijkheden voor een ‘Nederlandse terugkeer’…

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

What is leadership? Can it be taught, and if so, how? The International Leiden Leadership Programme (ILLP) helps students find their own style, say ILLP graduate Marko Simovski and his former coach Annah Neve in an interview: 'It’s about you, discovering you.'

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

Wil jij je mening laten horen over de opleiding, de faculteit en de universiteit en lijkt het je leuk om met een bestuurder in gesprek te gaan? Geef je op en misschien ben jij een van de studenten die wordt geselecteerd voor de lunchbijeenkomst op 5 juli 2017 met assessor Aurelie van ’t Slot en vice-decaan…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Dit artikel presenteert een systematische review van verschillende trainingsmethoden op het gebied van cyberbeveiliging.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Kasteren

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Is er sprake van een tanende legitimiteit van het recht en bestuur in een veellagige rechtsorde en welke betekenis heeft (afnemende) legitimiteit voor de effectiviteit van het recht?

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Possible improvements for the assessment of abiotic depletion in LCA.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Sociaaleconomisch Beleid: Empirische Analyse, een nieuw vak voor bachelorstudenten Bestuurskunde die de richting Economie, Bestuur en Management volgen.

Promotor: W.T. de Groot

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: H.J.M. de Groot

Promotor: J. A. Bouwstra

This thesis describes a study from both a theoreticaL and an experimental point of view.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren

Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.