1,680 zoekresultaten voor “is a and petra” in de Publieke website
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Unraveling cross-presentation pathways using a chemical biology approach
Kasteren
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Untangling cosmic collisions: a study of particle acceleration and magnetic fields in merging galaxy clusters
On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.
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Conversation with Dr Graça Machel: intergenerational justice from a human rights perspective
Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…
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The Legitimacy and Effectiveness of Law & Governance in a world of multilevel jurisdictions
Is er sprake van een tanende legitimiteit van het recht en bestuur in een veellagige rechtsorde en welke betekenis heeft (afnemende) legitimiteit voor de effectiviteit van het recht?
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Suppressing a Sea of Starlight: Enabling technology for the direct imaging of exoplanets
Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik
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On the geometry of demixing: A study of lipid phase separation on curved surfaces
Like a mixture of oil and water, lipid membranes separate into two liquid phases.
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Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries
Promotor: W.T. de Groot
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Superlattices in van der Waals materials: A Low-Energy Electron Microscopy study
n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Transport coefficients and low energy excitations of a strongly interacting holographic fluid
In this thesis, classes of strongly interacting quantum field theories, have been studied.
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Student for a Day - MSc Crisis and Security Management, spec. Governance of Crisis
Studievoorlichting
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Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
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Picturing Intimacy: Mediation and Self-representation in a Boston’s Religious Festivals
Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.
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The Diving Dutchman: het marien-gravimetrisch onderzoek van F.A. Vening Meinesz (1887-1966)
Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra
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Facets of radio-loud AGN evolution: a LOFAR surveys perspective
Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren
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The details of past actions on a smartphone touchscreen are reflected by intrinsic sensorimotor dynamics
Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
- Nederlands voor Vergevorderden A (start in september) en B (start in februari)
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: Prof.dr. J.N. Kok
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The Miliuseae revisited: phylogenetic, taxonomic, and palynological studies in a major clade of Annonaceae
Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou
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A molecular journey : tales of sublimating ices from hot cores to comets
The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Develop a methodology for assessing the effective dose of nanomaterials for environmental risk assessment purposes
How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?
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changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Child Marriage as a Choice: Rethinking agency in international human rights
Op 18 maart 2020 verdedigde Hoko Horii haar proefschrift 'Child Marriage as a Choice: Rethinking agency in international human rights'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. G.A. van Klinken (UvA).
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dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Withstanding the cold: energy feedback in simulations of galaxies that include a cold interstellar medium
Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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Explicit Computation of the Height of a Gross-Schoen Cycle
Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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From the root of variation: A metabolomics perspective to plant soil-feedback
By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Functionalizing monolayer graphene as a proton-selective membrane for direct methanol fuel cells
This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.
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The implementation of international law in the national legal order: A legislative perspective
Op 5 juni 2018 verdedigde Emile Beenakker zijn proefschrift getiteld ‘The implementation of international law in the national legal order: A legislative perspective’. Het promotieonderzoek is begeleid door promotor professor W.J.M. Voermans.
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The writing culture of ancient Dadan; a description and quantitative analysis of linguistics variation
Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019
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A culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.
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Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice
Miriam Cohen verdedigde haar proefschrift genaamd “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” op 28 juni 2017. Ze schreef haar proefschrift onder supervisie van prof.dr. L.J. van den Herik en prof. dr. C. Stahn.
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Effectiveness of audience segmentation in instructional risk communication: A systematic literature review
This article provides a list of the concepts and key elements that should be considered when creating effective communication messages.