615 zoekresultaten voor “medicine op make” in de Publieke website
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Social network and radical innovation: evidence from the U.S. pharmaceutical and biotechnology industry
Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotores: T.H. Oosterkamp, N. de Jonge
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On the optimization of imaging pipelines
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…
- Masterclass: Why did Pope Gregory the Great make churches give up property? (Roy Flechner, University College Dublin)
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Open label placebo voor jeuk
Positieve verwachtingen kunnen het gevoel van jeuk beïnvloeden en placebo-effecten oproepen, terwijl negatieve verwachtingen nocebo-effecten bij jeuk kunnen veroorzaken. Er zijn aanwijzingen dat placebo-effecten ook kunnen optreden wanneer mensen weten dat zij een placebo innemen. Er is weinig bekend…
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Van data naar inzichten
Sociaal wetenschappelijk onderzoek leert ons om menselijk gedrag en maatschappelijke structuren te begrijpen. Deze worden bepaald door veel verschillende factoren. Dat maakt het onderzoek complex en vergroot de kans op onterechte conclusies. Het kiezen van de onderzoeksmethoden en analyses is dan ook…
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Vasculaire en Regeneratieve Geneeskunde
Behandelmethoden voor chronische ziekten zijn beperkt. Artsen en onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken aan nieuwe therapieën als alternatief voor orgaantransplantatie. Doel is om organen te herstellen in hun oorspronkelijke functie en op die…
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Duurzaamheid in het Onderwijs
Kijk regelmatig op deze pagina voor meer informatie over het inpassen van duurzaamheid in het onderwijs van de Universiteit Leiden.
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Geneeskunde
De Faculteit Geneeskunde
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Onze mensen
Maak kennis met de mensen van ons team.
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Leiden Academic Centre for Drug Research
Het ontwikkelen van nieuwe medicijnen is een complex proces waarbij veel partijen samenwerken. De onderzoekers van het LACDR zetten zich dagelijks in voor nieuwe, betere, efficiëntere en makkelijker produceerbare medicijnen. Het instituut werkt nauw samen met het LUMC, met bedrijven op het Leiden Bio-Science…
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Na je studie
Na de bachelor kun je doorstromen in onze master Geneeskunde. Rond je die ook succesvol af, dan ben je basisarts. Daarna kun je je specialiseren, promotieonderzoek doen, of werken als basisarts.
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Simcha Jong Kon Chin
Wiskunde en Natuurwetenschappen
s.jong@liacs.leidenuniv.nl | +31 71 527 7201
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Marjolein Fokkema
Faculteit der Sociale Wetenschappen
m.fokkema@fsw.leidenuniv.nl | +31 71 527 7996
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Assembling anisotropic colloidal building blocks
This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
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Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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The holographic glass bead game: from superconductivity to time machines
Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm
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Cryptography from quantum uncertainty in the presence of quantum side information
Promotor: Ronald Cramer, Co-promotor: Serge Fehr
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ALL-IN meta-analysis
Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Designing 'context-specific' regional innovation policy: a study on the role of regional government in six European regions
Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…
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Flows of six heavy metals
Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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The Proliferation of Dissenting Opinions in International Law
Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).
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Lights in a sea of darkness: constraining the nature and properties of dark matter using the stellar kinematics in the centres of ultra-faint
Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.
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Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Onderwijs
In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…
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Compressed Σ-Protocol Theory
In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.
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Positive representations of algebras of continuous functions
If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Scheduled protocol programming
With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…
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Probing the properties of dark matter particles with astrophysical observations
It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Prosecutorial Discretion in International Criminal Justice
Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!
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Automated machine learning for dynamic energy management using time-series data
Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!
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Studentenleven
Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!