Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Promotor: Prof.dr. A.G.G.M. Tielens

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

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Binnen Una Europa vindt academische samenwerking plaats in interdisciplinaire zelfsturende comités (SSC’s).

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

Na de master kiezen de meeste alumni voor een baan in het bedrijfsleven of bij de overheid.

Is het mogelijk om ziektes te diagnosticeren met behulp van moleculaire schakelaars? Over die vraag buigt het nieuwe internationale consortium LogicLab zich. Vanuit Leiden zijn scheikundige Sylvestre Bonnet en farmacoloog Thomas Hankemeier betrokken. Het project loopt voor vier jaar en krijgt ruim 3,5…

Promotie

Promotie

De Leiden University Centre for the Study of Religion (LUCSoR), the Dutch Association for the Study of Religion (NGG), The Netherlands School for Advanced Studies in Theology and Religion (NOSTER) in samenwerking met de University of Erfurt Research Centre

The University of Oslo offers a two-year senior researcher position with focus on early medieval Latin additions with musical notation. The successful applicants will join the MINiTEXTS research group at the department (up to 10 group members) with regular activities, internal seminars, workshops, and…

The University of Oslo offers two three-year postdoctoral positions: one with a background in early medieval liturgy and the other in early medieval cultures of healing. The successful applicants will join the MINiTEXTS research group at the department (up to 10 group members) with regular activities,…

The University of Oslo offers two three-year PhD positions with focus on specific early medieval Latin textual additions. The successful applicants will join the MINiTEXTS research group at the department (up to 10 group members) with regular activities, internal seminars, workshops, and conferences.…

Promotor: Prof.dr. H.S. Overkleeft

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: A.P. IJzerman

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Promotor: A.P. IJzerman