1,569 zoekresultaten voor “role work in role environmental” in de Publieke website
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Ecological functioning of bacterial chitinases in soil
Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Shining Light on PAHs in Space
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…
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The good? The bad? The mutant! Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine
G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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The effects of burying beetle social behaviours on interspecific interactions
This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Diversity in the globally intertwined giant barrel sponge species complex
This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Agenda dynamics in the European Union : the interaction between the European Council and the European Commission in the policy domain of organized
The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
- ELS lab meeting - Work in Progress Session: Working from Home: what empirical questions arise? by Merel Cornax
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PhD Candidate, Brain-inspired LLM for Edge Devices: A Hardware-Algorithm Co-design Framework
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Public lecture: 'The ocean’s role in mitigating climate change'
Lezing
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Assistant Professor in Automated Reasoning (0.8-1.0 FTE)
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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International Environmental Obligations and Liabilities in Deep Seabed Mining
Op dinsdag 26 juni 2018 verdedigt Linlin Sun haar proefschrift ‘International Environmental Obligations and Liabilities in Deep Seabed Mining’. De promotoren zijn prof. dr. N.J. Schrijver en prof. dr. E.C.P.D.C. De Brabandere.
- ELS lab meeting - Work in Progress Session: Case study on dispute resolution technology by Nikki Vosters
- ELS lab meeting - Work in Progress: Survey of EU Member States by Eva Grosfeld
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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Onderwijs- en organisatieontwikkeling
Publicaties Onderwijs- en organisatieontwikkeling
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Multifaceted role of the complement system in health and disease
Promotie
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Role of intestinal microbiota in cardio-metabolic disease
Promotie
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Seeing voices: the role of multimodal cues in vocal learning
Promotie
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Understanding the Surface Structure of Catalysts and 2D Materials at the Atomic Scale
The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.
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Werkplan Diversiteit & Inclusie
Zie hier het facultaire werkplan voor diversiteit en inclusie binnen de Faculteit der Rechtsgeleerdheid.
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Online Course International Law in Action: The Arbitration of International Disputes
This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…
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Online Course International Law in Action: A Guide to the International Courts and Tribunals in The Hague
This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Insights from scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Robert Verpoorte
Wiskunde en Natuurwetenschappen
verpoort@chem.leidenuniv.nl | +31 71 527 4528
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PhD: sustainability & circularity-based decision support systems (industrial digital twins)
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Adding fuel to the conflict : how gas reserves complicate the Cyprus question
In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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A time-space translation mechanism for patterning the vertebrate anteroposterior axis
My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.