563 zoekresultaten voor “synthesis he biology” in de Publieke website
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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FAQ over Health, Ageing and Society
Hieronder kun je een antwoord vinden op de meestgestelde vragen over de master. Wordt jouw vraag niet beantwoord? Neem gerust contact met ons op voor een gepersonaliseerd antwoord via: masterhas@lumc.nl.
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PhD candidate - biodiversity & society: the Dutch home as a multispecies space
The Faculty of Science is looking for a:PhD candidate - biodiversity & society: the Dutch home as a multispecies spaceVacancy number: 14709 Project descriptionA substantial part of biodiversity is situated within private spheres of homes and this is also the biodiversity that most intimately affects…
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Assistant Professor in Protein Design
The Leiden Institute of Chemistry (Faculty of Science) is looking for:Assistant Professor in Protein DesignVacancy number: 14676 The Leiden Institute of Chemistry (LIC) aims to hire a talented researcher at the level of assistant professor with an interest in the design and application of artificial…
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DNAmarkerpoint
DNAmarkerpoint heeft als doel ecologie, evolutie en biodiversiteit beter te begrijpen door het bestuderen van modern en ancient DNA.
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Potential interference of fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.
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Assistant/Associate professor in Quantitative Ecology (0.8-1.0 fte)
The Faculty of Science and Institute of Environmental Sciences (CML) are looking for:Assistant/Associate professor in Quantitative Ecology (0.8-1.0 fte) Vacancy number: 14846 Key responsibilitiesLeiden University's Institute of Environmental Sciences (CML) is inviting applicants for a faculty position…
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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Studying through the summer?
Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…
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Sustainable Chemistry and Biotechnology
If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…
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Human Evolution
This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…
- Van Darwin tot DNA
- Onderzoeksfaciliteiten
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Two-Prover Bit-Commitments: Classical, Quantum and Non-Signaling
This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.
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De Ethiopische wolf: gerespecteerd én bedreigd door lokale veehouders
De zeldzame Ethiopische wolf komt steeds vaker in aanvaring met lokale veehouders. Promovendus Girma Eshete zocht naar manieren om het elegante beest te redden van de ondergang. Promotie op 5 september.
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Wil Tamis
Wiskunde en Natuurwetenschappen
tamis@cml.leidenuniv.nl | +31 71 527 2727
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Esther van der Ent
Wiskunde en Natuurwetenschappen
e.van.der.ent@cml.leidenuniv.nl | +31 71 527 2727
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Hermen Overkleeft
Wiskunde en Natuurwetenschappen
h.s.overkleeft@chem.leidenuniv.nl | +31 71 527 5037
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Systems biology as a compass to understand cancer-immune interactions in humans
Promotie
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Duurzame toekomst
Hoe kunnen we onze maatschappij zo inrichten dat de wereld leefbaar blijft voor onszelf en al het andere leven om ons heen? Aan dat vraagstuk werken Leidse wetenschappers samen vanuit allerlei disciplines, van biologie tot datawetenschap en van milieueconomie tot archeologie.
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PhD in Formal Methods for Quantum Compilation (1.0 FTE)
The Faculty of Science, Leiden Institute of Advanced Computer Science, is looking for candidates for a: PhD in Formal Methods for Quantum Compilation (1.0 FTE) We are looking for individuals with an excellent academic record interested in the development and implementation of new classical data structures…
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PhD position in 'Effects of Pollution at the Ecosystem Level'
Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)
- PhD: Targeting electron transport chain in Listeria monocytogenes for novel antibiotic development
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Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
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Vossenjacht
'Hé kijk, daar staat Rembrandt van Rijn! En is dat niet Beatrix?' Als je goed zoekt loop je tijdens de 444-vossenjacht op 29 juni allerlei beroemdheden uit heden en verleden tegen het lijf.
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Prosecutorial Discretion in International Criminal Justice
Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.
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Onderzoek
Steden, Voedsel, Water, Biodiversiteit, Bronnen en Energie: dit zijn de belangrijkste onderzoeksthema’s voor het CML. Ons doel is altijd om wereldwijd voorop te lopen in ons vakgebied. En echte impact te hebben met onze onderzoeksprogramma’s.
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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PNEC-pro
PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Optical properties of DNA-hosted silver clusters
Promotor: D. Bouwmeester, Co-promotor: D. Kraft
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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Analysis and Stochastics
The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.
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Dynamic organization of bacterial chromatin by DNA bridging proteins
Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.
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Towards Optical Detection of a Single Electron
Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink