All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

This project, South American population history revisited: multidisciplinary perspectives on the Upper Amazon (SAPPHIRE), investigates population dynamics in western South America on the basis of traces in the geographical, genetic, archaeological, ethnological, and linguistic record.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Governance and Global Affairs, Instituut Bestuurskunde

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.

Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

Heeft het gebruik van medicijnen en drugs invloed op mijn persoonlijkheid? Wat zijn de (langere-termijn) gevolgen van de leerpil 'Ritalin'? Kunnen (party)drugs en medicijnen met rijden in het verkeer samengaan? Wat doen verslavende stoffen met mijn brein?

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Wiskunde en Natuurwetenschappen

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Including modelling as part of software development appears to have various benefits.

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Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.

Hoe kunnen studenten in mbo- en hoger onderwijsinstellingen het beste worden ondersteund in hun studiekeuze en studieloopbaan met het oog op soepele in- en doorstroom in opleiding en werk?

Dit artikel wil een coherente basis bieden voor empirische studies naar interpersoonlijke discussies over risico's.

In dit artikel onderzochten Martin Sievert en Jonas Bruder of en hoe administratieve lasten van invloed zijn op de perceptie van burgers van het welzijnsbeleid en hun houding tegenover uitkeringsgerechtigden.