Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

Promotores: J. Zaanen, A. Parnachev

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

EuDEco (modellering van de Europese Data Economie) is een Coordination & Support Action (CSA) die financiering ontvangt van het Europese Horizon 2020 programma.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Kunst en cultuur, Studium Generale | Theatervoorstelling

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Deze digitale gastlessen behandelen thema's als economie, recht, bestuur, gedrag en maatschappij.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Op deze pagina vindt u het overzicht van zowel de aankomende als de afgeronde alumniwebinars/masterclasses van de Universiteit Leiden. Bij elk afgerond webinar/masterclass vindt u de link naar de opname.

Hieronder de beschrijvingen van de LHSC aanjaagsubsidies die zijn toegekend. Deze samenvattingen zijn opgesteld voor het brede publiek. Voor meer informatie kun je contact opnemen met de genoemde wetenschappers.

Psycho-physiologische reacties op stress.

Lezing

Werk kan niet altijd leuk zijn, maar wat als alleen al een blik op de to do-lijst buikpijn bezorgt? Om het gesprek daarover te starten, ging de zesde Psychology Connected over werkdruk en werkplezier. Mét tips uit de positieve psychologie.

Bernet Elzinga (Klinische psychologie) ontvangt met de Vici-beurs uit de Vernieuwingsimpuls van de nationale wetenschapsorganisatie NWO een van de grootste subsidies voor individuele onderzoekers. Deze subsidie heeft ze gekregen voor haar project 'Unravelling the Impact of Emotional Maltreatment on…

Het onderzoek van het Resilience Center gaat over geestelijke gezondheidsrisico's en veerkracht bij jongeren. We doen dit door culturele, sociale, cognitieve en neurobiologische factoren en hun interacties te integreren.

Promotie

Prof.dr. H. van Attikum

Hoe dragen verschillende levensloopfactoren bij aan financiële kwetsbaarheid onder gepensioneerden in Nederland, en hoe kunnen gerichte interventies en beleidsmaatregelen de financiële weerbaarheid van deze groepen vergroten?

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Het ‘Leer te Durven!’ programma is een preventieve training voor kinderen met lichte angstklachten (Simon & Bögels, 2014). Het programma is speciaal ontwikkeld voor kinderen tussen de 8 en 12 jaar die zich angstig voelen of angstig gedragen, situaties vermijden, bang zijn om dingen fout te doen, schrikachtig…

Het doel van ons onderzoeksprogramma Klinische Psychologie is om de etiologie en het verloop van stemmings-, angst- en stress-gerelateerde aandoeningen zoals depressie en posttraumatische stressstoornis (PTSS) beter te begrijpen.

The global agri-food system plays a critical role in food security and environmental issues.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Met het SAPPAO-project willen we de voorspelling van geplande vluchten nauwkeuriger en betrouwbaarder maken. De volledige naam van het project is ‘A Systems Approach towards Data Mining and Prediction in Airlines Operations’.

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.