814 zoekresultaten voor “applied ethiek” in de Publieke website
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Stock-driven Scenarios on Global Material Demand
The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Mining the kinematics of discs to hunt for planets in formation
Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…
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Methods and Tools for Mining Multivariate Time Series
Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Multi-objective mixed-integer evolutionary algorithms for building spatial design
Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Software developments in automated structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Corporate venture management in SMEs: evidence from the German IT consulting industry
Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)
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Combining monitoring with run-time assertion checking
Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue
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Towards a Sustainable and Circular Metals Economy
In-use stocks of products can be considered as intermediaries between human needs and the physical world.
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Are nanoplastics dangerous to your health?
Lezing, NGL-lezing
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Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
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Photoinduced processes in dye-sensitized photoanodes under the spotlight: a multiscale in silico investigation
With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Systemic Accountability of the European Border and Coast Guard
Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Cross-border Claims to Cultural Objects
Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Voorlichtingsactiviteiten
Kom naar onze online en oncampus events om ons beter te leren kennen!
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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Insights into the mechanism of electrocatalytic CO2 reduction and concomitant catalyst degradation pathways
This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Student for a day Dutch Studies
Studievoorlichting
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Ecology of the Ethiopian wolf (Canis simensis Rüppell 1835) in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of
Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.
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On the Emergence of the Energy Transition
The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.
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Student for a day Arts, Media and Society
Studievoorlichting
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Organisatie
Het Mathematisch Instituut heeft een lichte managementstructuur. Taken zijn gespreid over de staf. Belangrijke beslissingen worden genomen per consensus. Hieronder worden diverse organisatieonderdelen toegelicht.
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Een rockster in een petrischaaltje
Met 's werelds eerste neurale synthesizer treden kunstenaar Guy Ben-Ary en zijn collega’s op tijdens het TodaysArt Festival in Den Haag op 21 september. Voor deze performance werkte hij samen met het lab van Erik Danen om neurale stamcellen te transformeren tot neurale netwerken op een chip.
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Bart Custers in Nieuwsuur over gezichtsherkenning
Hoewel specifieke wetgeving ontbreekt mag de politie van minister Yeşilgöz (Justitie en Veiligheid) experimenteren met gezichtsherkenningstechnologie. Sinds 2019 mocht de politie dit niet omdat er geen juridische en ethische waarborgen voor waren. Maar de politie ontwikkelde ongeveer een jaar geleden…
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Over de opleiding
In de opleiding Filosofie bestudeer je de theorieën van klassieke en hedendaagse denkers. Je ontwikkelt een kritische houding, en leert gestructureerd nadenken, nauwkeurig redeneren en zorgvuldig formuleren.
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Studieprogramma
Binnen de opleiding Filosofie richt je je op verschillende deelgebieden binnen de westerse filosofie.
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Beleid, Bestuur en Organisatie (BSc)
Bij de Bestuurskunde specialisatie Beleid, Bestuur en Organisatie analyseer je actuele vraagstukken zoals de woningcrisis, energietransitie en immigratie. Je leert hoe beleid ontstaat en hoe publieke organisaties functioneren vanuit verschillende invalshoeken.
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Digitalisering, Bestuur en Maatschappij (BSc)
De Bestuurskunde specialisatie Digitalisering, Bestuur en Maatschappij bereidt je voor op een toekomst waarin digitale vraagstukken en bestuur verweven zijn. Je leert ontwikkelingen zoals AI te vertalen naar concreet beleid en verantwoord werken met technologie in het openbaar bestuur.
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Onderzoek
Aan de Universiteit Leiden werken wetenschappers uit alle disciplines samen om antwoorden te vinden en om te innoveren op het gebied van kunstmatige intelligentie.
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Onderwijs voor professionals
Wilt u zich verder ontwikkelen en op academisch niveau uitgedaagd worden in uw vakgebied of daarbuiten? De Leiden Law Academy van de Universiteit Leiden heeft een breed geaccrediteerd juridisch opleidingsaanbod om uw carrière een boost te geven, nieuwe vaardigheden te leren of uw kennis te verbreden.…
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Onderwijs
Het onderwijs aan het Instituut Bestuurskunde richt zich op de brede studie van het openbaar bestuur, inclusief de semipublieke sector, lobbyorganisaties, het maatschappelijk middenveld en relevante private organisaties.
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Onderzoek
Het Instituut Politieke Wetenschap heeft een zeer divers onderzoeksprogramma. Dit programma dient twee doelen: het bevorderen van de eenheid van het Instituut als een intellectuele gemeenschap van sociale wetenschappers en politicologen en om collega’s met overlappende interessegebieden in staat te…
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Ethische toetsing
Wetenschappers hebben afgesproken om vanuit 5 principes te werken in hun onderzoek:
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Langs tragische einders
Langs tragische einders. Verkenningen in de esthetica van moraal en recht
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Organisatie
De Leidse Faculteit der Archeologie is de grootste academische instelling voor Archeologie in Nederland en een van de grootste ter wereld. Ze behoort tot de internationale top en staat in de top tien van de QS World University Ranking per vakgebied.