1,563 zoekresultaten voor “cancer dat discovery initiatief” in de Publieke website
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Discovery of Antibiotics and Their Targets in Multidrug-Resistant Bacteria
Promotie
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Erik Danen wil tumoren vangen in hun eigen web
Erik Danen speurt met succes naar wegen om tumoren die slecht op medicijnen reageren de pas af te snijden. De hoogleraar Cancer Drug Target Discovery kijkt hiervoor naar de interactie tussen tumorcellen en hun omgeving. Oratie vrijdag 10 mei.
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Leiden Loves Science
Ben je op zoek naar een alternatieve Valentijnsavond? En gaat je hart sneller kloppen bij het horen over wetenschappelijke ontdekkingen? Kom dan naar Leiden Loves Science.
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Analysis and Stochastics
The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.
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Radio galaxies near the epoch of reionisation
This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.
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Hunting dark matter with X-rays
Promotor: A. Achúcarro Co-promotor: A. Boyarsky
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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De sociale geschiedenis van arbeid in de Iraanse olie-industrie (1908-1954)
This PhD research sets out to unravel and explain the socio-structural and cultural impacts of oil-industrialization on the local Bakhtiari community in general and the industrial laborers it provided in specific.
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Nanofluidic tools for bioanalysis : the large advantages of the nano-scale
Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Pattern mining for label ranking
Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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The T cell-myeloid axis in the success and failure of cancer immunotherapy
Promotie
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Molecular approaches to identify cancer T cell antigens and improve immunogenicity
Promotie
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Nanoparticle-based combination drug delivery systems for effective cancer treatment
Promotie
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Targeting MHC-I related proteins for cancer diagnosis and therapy
Promotie
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the response to immunotherapy in patients with non- small cell lung cancer
Promotie
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Multifaceted Roles of Grainyhead-like Transcription Factor- 2 in Breast Cancer
Promotie
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Screening the CITY: Optimizing population-based cancer screening in the Netherlands from a primary care perspective
Promotie
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Adding fuel to the conflict : how gas reserves complicate the Cyprus question
In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Early death of massive galaxies in the distant universe
Promotor: M. Franx, Co-Promotor: I.F. Labbé
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Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Hydrodynamics and the quantum butterfly effect in Black Holes and large N quantum field theories
Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?
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Lava worlds: characterising atmospheres of impossible nature
Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune.
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Cryo Electron Tomography Studies On Bacterial Chemosensory Arrays
Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.
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Laura Heitman benoemd tot Hoogleraar Moleculaire farmacologie
Per 1 november is Laura Heitman benoemd tot hoogleraar Moleculaire farmacologie bij het Leiden Academic Centre for Drug Research (LACDR). Heitman draagt bij aan de ontdekking van nieuwe geneesmiddelen door onderzoek naar de interactie tussen medicijnen en hun aangrijppunt in het lichaam. ’Mijn uiteindelijke…
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Targets for Improving Patient Outcomes after Major Gastrointestinal Cancer Surgery: The value of peri-operative care
Promotie
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for the evaluation of experimental therapy in prostate and bladder cancer
Promotie
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delivery of viral epitopes to redirect virus-specific CD8+ T cells to cancer cells
Promotie
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Sleep and learning in children
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Studieprogramma
Bij Biomedische wetenschappen word je opgeleid tot wetenschapper in het biomedisch veld. Wat houdt dat eigenlijk precies in en wat leer je allemaal in de bachelorfase?
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Adaptive Semi-Strong Ecosystem Dynamics
Developing methodes to understand the evolution of patches in natural ecosystems
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Sebastian Pomplun treedt toe tot Oncode Institute om doorbraken in het kankeronderzoek te versnellen
Met medicijnen eiwitten bereiken die onbereikbaar leken. Dat lukt Sebastian Pomplun. Daarom mag hij met zijn onderzoeksgroep toetreden tot Oncode Institute. Met negen anderen is hij uit 72 kandidaten geselecteerd om bij te dragen aan de missie van Oncode Institute: doorbraken in het kankeronderzoek…
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Gerard van Westen: 'Ons model voorspelt wat kandidaat-medicijnen doen in je lijf'
Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…