2,421 zoekresultaten voor “cancer drug discovery initiatief” in de Publieke website
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Optimizing clinical management of T1 colorectal cancer
Promotie
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Experimental optical imaging during pancreatic cancer interventions
Promotie
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Immuno-photodynamic therapy of cancer
Promotie
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Friso Stevens bij BNR Nieuwsradio over het infrastructuur initiatief 'Global Getaway'
Friso Stevens, promovendus aan het Institute of Security and Global Affairs, was afgelopen week te beluisteren bij BNR Nieuwsradio Breekt.
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Joanne van der Leun met initiatief Leiden Law Park in Leidse Top 50
Op Internationale Vrouwendag 2020 is de eerste editie van de Leidse Top 50 bekendgemaakt. Op de lijst staan 50 vrouwen die het afgelopen jaar in Leiden het verschil hebben gemaakt.
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Antoni van Leeuwenhoek en LUMC slaan handen ineen voor immuuntherapie
Het eigen afweersysteem van een kankerpatiënt versterken zodat het lichaam zelf beter kankercellen kan vernietigen. Het is de kern van immuuntherapie, de hoopgevendste vooruitgang binnen de behandeling van kanker van de afgelopen jaren. Om deze ontwikkeling verder aan te jagen slaan het Antoni van Leeuwenhoek/Nederlands…
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Roxanne KieltykaWiskunde en Natuurwetenschappen
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Leukemia treatment & cognitive development
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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De geheimzinnige krachten van pericyten
Leidse onderzoekers hebben een manier gevonden om de minieme krachten te meten die worden veroorzaakt door pericyten, een van de meest ongrijpbare celtypes in het lichaam, die deel uitmaken van haarvaten. Zulk onderzoek zou op den duur kunnen leiden tot behandelingen voor aandoeningen als ischemie.
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Twee Bio-Farmaceutische Wetenschappers winnen KNMP Studentenprijs
Twee oud-studenten Bio-Farmaceutische Wetenschappen winnen dit jaar de KNMP Studentenprijs. Esmée de Zwaan voor haar onderzoek naar nieuwe therapeutische strategieën, Sanne Bakker voor een studie naar bloedingsrisico’s bij gebruik van het antidepressivum SSRI. Apothekersorganisatie KNMP reikte de jaarlijkse…
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Promotie
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Patient-derived models of breast cancer: A breakthrough story of the duct
Promotie
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BRCA1-associated breast cancer: finding new weapons for an old villain
Promotie
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Cancer-induced somatic mutations in G protein-coupled receptors
Promotie
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Arco Timmermans over opvallend veel geschrapte verwijzingen naar staalindustrie in definitief GGD-rapport over longkanker in de Ijmond
Arco Timmermans, Bijzonder Hoogleraar Public Affairs aan het Instituut Bestuurskunde, besprak bij EenVandaag de opvallende verandering in het in juni gepubliceerde GGD-rapport over kanker rond Beverwijk.
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Paul Abels in NRC over de rol AIVD bij strijd drugshandel
Minister Grapperhaus wil inlichtingendiensten bij de opsporing van drugscriminaliteit inzetten. In de inlichtingenwereld bestaan veel aarzelingen over deze wens. Paul Abels, Bijzonder Hoogleraar Governance of Intelligence and Security Services aan het Insitute of Security and Global Affairs (ISGA) spreekt…
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Universiteit Leiden en Bayer leiden internationale samenwerking voor ontwikkeling nieuwe medicijnen
De Universiteit Leiden start samen met Bayer HealthCare een internationaal consortium ‘Kinetics for Drug Discovery’ (K4DD) dat onderzoek gaat doen naar optimaliseren van de ontwikkeling van nieuwe geneesmiddelen.
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Improving Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer
Promotie
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Exploring liposome-targeted chemotherapy combined with immunotherapy in cancer
Promotie
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Predicting outcomes of breast cancer treatment in older patients
Promotie
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Unraveling mucin type o-glycosylation signatures of colorectal cancer
Promotie
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Characterization of candidate genes in unexplained polyposis and colorectal cancer
Promotie
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The tumor-stroma ratio in epithelial cancer types
Promotie
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Management and priorities of older patients with multimorbidity and cancer
Promotie
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Towards personalized treatment for high risk endometrial cancer
Promotie
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Understanding the complexity of TGF-beta signaling in cancer
Promotie
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Refining individualized treatment in older patients with breast cancer
Promotie
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Quality assessment and multi modalty in gastric cancer treatment
Promotie
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Diagnostic challenges of today's lung cancer pathology
Promotie
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Early Detection of Pancreatic Cancer in High-Risk Individuals
Promotie
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
Promotie
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Antibiotic Discovery: From mechanistic studies to target ID
Promotie
- Verslaving: waarom kan je niet stoppen met...?
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Judith BovéeFaculteit Geneeskunde
j.v.m.g.bovee@lumc.nl | +31 71 526 9111