1,442 zoekresultaten voor “cancer drug discovery initiative” in de Publieke website
-
Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
-
De impact van onze producten en diensten op het milieu en klimaat: hoe te meten?
De auto die we kopen is gemaakt van duizenden componenten, die weer gemaakt zijn van verschillende typen materialen. Deze materialen zijn op zichzelf weer afkomstig van verschillende plekken, worden naar productiefaciliteiten gestuurd en verzameld tot een product. Zodra de auto afgedankt is, moeten…
-
Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
-
Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
-
Leukemia treatment & cognitive development
-
-
Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
-
De geheimzinnige krachten van pericyten
Leidse onderzoekers hebben een manier gevonden om de minieme krachten te meten die worden veroorzaakt door pericyten, een van de meest ongrijpbare celtypes in het lichaam, die deel uitmaken van haarvaten. Zulk onderzoek zou op den duur kunnen leiden tot behandelingen voor aandoeningen als ischemie.
-
Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
-
Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
-
Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
-
Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
-
Twee Bio-Farmaceutische Wetenschappers winnen KNMP Studentenprijs
Twee oud-studenten Bio-Farmaceutische Wetenschappen winnen dit jaar de KNMP Studentenprijs. Esmée de Zwaan voor haar onderzoek naar nieuwe therapeutische strategieën, Sanne Bakker voor een studie naar bloedingsrisico’s bij gebruik van het antidepressivum SSRI. Apothekersorganisatie KNMP reikte de jaarlijkse…
-
Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
-
In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
-
Disrupting the transcriptional machinery to combat triple-negative breast cancer
Promotie
-
Patient-derived models of breast cancer: A breakthrough story of the duct
Promotie
-
BRCA1-associated breast cancer: finding new weapons for an old villain
Promotie
-
Cancer-induced somatic mutations in G protein-coupled receptors
Promotie
-
Arco Timmermans over opvallend veel geschrapte verwijzingen naar staalindustrie in definitief GGD-rapport over longkanker in de Ijmond
Arco Timmermans, Bijzonder Hoogleraar Public Affairs aan het Instituut Bestuurskunde, besprak bij EenVandaag de opvallende verandering in het in juni gepubliceerde GGD-rapport over kanker rond Beverwijk.
-
Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
-
Transnational Pentecostalism in the Age of #MeToo: Sexual Violence and Harassment from Lagos to Los Angeles
This initiative is intended to support generative research collaborations between and among scholars located in different geographical regions who wish to pursue focused, joint projects in any area of the study of religion.
-
Constraints on large-scale implementation of BioSolarCells, Early stage assessment of environmental value propositions
What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?
-
EU JudgeCo Platform
The ultimate aim of this project is to improve cooperation between courts in different Member States.
-
Paul Abels in NRC over de rol AIVD bij strijd drugshandel
Minister Grapperhaus wil inlichtingendiensten bij de opsporing van drugscriminaliteit inzetten. In de inlichtingenwereld bestaan veel aarzelingen over deze wens. Paul Abels, Bijzonder Hoogleraar Governance of Intelligence and Security Services aan het Insitute of Security and Global Affairs (ISGA) spreekt…
-
Characterization of candidate genes in unexplained polyposis and colorectal cancer
Promotie
-
The tumor-stroma ratio in epithelial cancer types
Promotie
-
Exploring liposome-targeted chemotherapy combined with immunotherapy in cancer
Promotie
-
Unraveling mucin type o-glycosylation signatures of colorectal cancer
Promotie
-
Predicting outcomes of breast cancer treatment in older patients
Promotie
-
Diagnostic challenges of today's lung cancer pathology
Promotie
-
Management and priorities of older patients with multimorbidity and cancer
Promotie
-
Towards personalized treatment for high risk endometrial cancer
Promotie
-
Early Detection of Pancreatic Cancer in High-Risk Individuals
Promotie
-
Improving Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer
Promotie
-
Refining individualized treatment in older patients with breast cancer
Promotie
-
Understanding the complexity of TGF-beta signaling in cancer
Promotie
-
Quality assessment and multi modalty in gastric cancer treatment
Promotie
-
Judith BovéeFaculteit Geneeskunde
j.v.m.g.bovee@lumc.nl | +31 71 526 9111
-
Antibiotic Discovery: From mechanistic studies to target ID
Promotie
-
Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
Promotie
- Verslaving: waarom kan je niet stoppen met...?
-
EuDEco case study report (D1.3)
D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…
- WHAT's NEW?! Lezingenreeks Voorjaar
-
Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
-
Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
-
The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
-
Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
-
Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
-
Katharina Krüsselmann bij omroep Brabant over explosies bij huizen en het beschieten van panden
Katharina Krüsselmann, promovendus aan het Institute of Security and Global Affairs, sprak bij Omroep Brabant over schietincidenten in Nederland, het onderwerp van haar promotieonderzoek.
-
Sebastian Pomplun treedt toe tot Oncode Institute om doorbraken in het kankeronderzoek te versnellen
Met medicijnen eiwitten bereiken die onbereikbaar leken. Dat lukt Sebastian Pomplun. Daarom mag hij met zijn onderzoeksgroep toetreden tot Oncode Institute. Met negen anderen is hij uit 72 kandidaten geselecteerd om bij te dragen aan de missie van Oncode Institute: doorbraken in het kankeronderzoek…