Promotor: J. N. Kok, Co-promotor: A. J. Knobbe

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Promotores: E. van Dijk, G.R. de Snoo. Co-promotor: H. Staats

Promotor: J.W.M. Frenken

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Een nieuw tweejarig masterprogramma Duits, verzorgd door vijf universiteiten, moet gaan voorzien in de grote vraag naar eerstegraads docenten Duits in het voortgezet onderwijs. De Universiteit Leiden is penvoerder van het programma.

Studeren in het buitenland gaat over meer dan alleen je studie. Laura Noordermeer is op uitwisseling in Seoul, Zuid-Korea en viel met haar neus in de boter: ze zag Suzanne Schulting de allereerste gouden medaille voor Nederland bij het shorttracken winnen!

Van 17 tot en met 21 augustus organiseert de Internationale Vereniging voor Neerlandistiek het Negentiende Colloquium Neerlandicum. Meer dan 250 hoogleraren en docenten uit bijna veertig landen strijken deze week neer aan de Universiteit Leiden om ervaringen uit te wisselen en nieuwe kennis op te doen…

De YAL laat zich horen over beleidskwesties.

What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

The main topic of this PhD thesis is the Arakelov ray class group of a number field, an algebraic object that contains both the ideal class group structure and the unit group structure.

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Wist je dat je na succesvolle afronding van de minor Chinese Economy and Society een aansluitende masteropleiding kunt volgen? Lees hier meer over de masteropleiding Asian Studies (MA).

De master History van de Universiteit Leiden heeft een sterk internationaal karakter en focust op Europese- en niet-Europese geschiedenis vanuit een globale context.

De master Asian Studies van de Universiteit Leiden is een hoogwaardige opleiding bij één van de meest vooraanstaande centra voor Aziëstudies in Europa.

Alumni-activiteit, Lezing

Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Door de opkomst van nieuwe methodes en technologieën, zoals verbeterde DNA-analyse en big data, is het archeologisch onderzoek de afgelopen decennia ingrijpend veranderd. De onderzoekers van het departement Archaeological Sciences van de Faculteit Archeologie gebruiken de nieuwe wetenschappelijke kennis…

For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent

Students Practicing Citizen Journalism

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotores: H. Schiessel, G.T. Barkema

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: D. Bouwmeester, Co-promotor: D. Kraft