Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Het onderzoek van de sectie Sociale, Economische en Organisatiepsychologie is gericht op het ontwikkelen van modellen om beïnvloeding in sociale systemen te beschrijven en te verklaren. Dit wordt onderzocht binnen het domein Sociale en Organisatiepsychologie, en ook binnen de Economische en Consumen…

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: Prof.dr. B.R. Katzy

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

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Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Het begrijpen van individuele verschillen in zelfregulatie bij jongens met ODD/CD op het niveau van het brein, cognitie en gedrag

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Op een ogenschijnlijk gewone kubus verschijnt onder druk een patroon van hollingen en bollingen. Er is nu een methode ontwikkeld om zulke 3 dimensionale structuren te ontwerpen en maken met eenvoudige bouwstenen. Publicatie in Nature.

Onderzoekers van het Leiden Institute of Physics en FOM-instituut AMOLF maakten een rubberen staaf die bij minder druk juist sneller doorbuigt. Een artikel over het onderzoek, in samenwerking met Harvard University, verscheen op 21 juli in Physical Review Letters.

Metamaterialen hebben eigenschappen die afhankelijk zijn van hun vorm en architectuur. Onderzoekers van AMOLF, Universiteit Leiden en de Universiteit van Tel Aviv vonden een nieuwe manier om deze metamaterialen en hun eigenschappen te ontwerpen door expres foutjes in te bouwen. Ze publiceren hun resultaten…

Een stukje geribbeld rubber functioneert als een eenvoudige computer, met geheugen en het vermogen om tot twee te tellen. Leidse natuurkundige onderzoekers publiceren erover in het tijdschrift PNAS. ‘Simpele materialen kunnen informatie verwerken, en wij zijn bezig de principes daarvan te achterhale…

Promotie

Promotie

In hun zoektocht naar materialen die zonder weerstand stroom geleiden bij gematigde temperaturen, sleutelen wetenschappers meestal aan de chemische samenstelling. Leidse natuurkundigen komen nu met een radicaal nieuwe benadering: gaatjes prikken in een periodiek patroon. Publicatie in SciPost.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Promotor: Prof.dr. H.S. Overkleeft

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Behavioral and neural mechanisms underlying self-concept development in relation to educational decision-making in adolescence

Op 7 februari 2019 verdedigde Helena Ursic-Vrabec haar proefschrift 'Uncontrollable: Data subject rights and the data- driven economy'. Het promotieonderzoek is begeleid door promotor prof. dr. S. van der Hof.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Op 3 juni 2021 verdedigde Vassilis Dafnomilis zijn proefschrift 'Taxation of Cross-border Inheritances and Donations'. Het promotieonderzoek is begeleid door promotoren prof.dr. F. Sonneveldt en prof. dr. S. Douma (UvA).

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.