Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotor: R. Cramer

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotor: W.T. de Groot

Promotor: J. Aarts

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: V. Vitelli, Co-promotor: J. Paulose

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotores: J. Zaanen, A. Parnachev

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotor: E.F. Smets, Co-promotor: J. Geml

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Onderwijs voor nieuwsgierige en ambitieuze studenten die meer uit hun studie willen halen!

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

This dissertation presents new cryptographic protocols, which can be divided into two families.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

Promotor: J.W. van Holten

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.